Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.54 |
| ▸ | ALOX15 | P16050 | 4/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.51 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.46 |
| ▸ | USP7 | Q93009 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | FPR1 | P21462 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3709475 | 0.84 | KDM4E (0.59) | ALDH1A1ALOX15LMNAKDM4ERXFP1 | |
| SCHEMBL3705035 | 0.80 | KDM4E (0.66) | ALDH1A1ALOX15LMNAKDM4ERXFP1 | |
| SCHEMBL3708815 | 0.80 | KDM4E (0.59) | ALDH1A1ALOX15LMNAKDM4ERXFP1 | |
| SCHEMBL3709876 | 0.80 | ALDH1A1 (0.74) | ALDH1A1ALOX15LMNAKDM4ERXFP1 | |
| SCHEMBL3709875 | 0.79 | ALOX15 (0.58) | ALDH1A1ALOX15LMNAKDM4ERXFP1 | |
| SCHEMBL16904821 | 0.79 | KDM4E (0.64) | ALDH1A1ALOX15LMNAKDM4ERXFP1 | |
| SCHEMBL3707576 | 0.79 | KDM4E (0.64) | ALDH1A1ALOX15LMNAKDM4ERXFP1 | |
| SCHEMBL3707667 | 0.78 | KDM4E (0.60) | ALDH1A1ALOX15LMNAKDM4ERXFP1 | |
| SCHEMBL3705340 | 0.78 | MEN1 (0.78) | ALDH1A1ALOX15LMNAKDM4ERXFP1 | |
| SCHEMBL3709481 | 0.78 | ALDH1A1 (0.66) | ALDH1A1ALOX15LMNAKDM4ERXFP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010081783-A1 | NOVEL SPECIFIC INHIBITORS OF UBIQUITIN SPECIFIC PROTEASE 7, THE PHARMACEUTICAL COMPOSITIONS THEREOF AND THEIR THERAPEUTIC APPLICATIONS | HYBRIGENICS SA (FR) | 2010-07-22 | — | — | WO | claimed |
| EP-2208725-A1 | Novel specific inhibitors of ubiquitin specific protease 7, the pharmaceutical compositions thereof and their therapeutic applications | Hybrigenics S.A. (FR) | 2010-07-21 | — | — | EP | claimed |
| EP-3923987-A1 | USE OF USP7 INHIBITORS FOR THE TREATMENT OF ACUTE MYELOID LEUKEMIA (AML) | Institut National de la Santé et de la Recherche Médicale (INSERM) (FR) | 2021-12-22 | — | — | EP | disclosed |
| WO-2020165315-A1 | USE OF USP7 INHIBITORS FOR THE TREATMENT OF ACUTE MYELOID LEUKEMIA (AML) | INSERM (Institut National de la Santé et de la Recherche Médicale) (FR) | 2020-08-20 | — | — | WO | disclosed |
| WO-2010081783-A1 | NOVEL SPECIFIC INHIBITORS OF UBIQUITIN SPECIFIC PROTEASE 7, THE PHARMACEUTICAL COMPOSITIONS THEREOF AND THEIR THERAPEUTIC APPLICATIONS | HYBRIGENICS SA (FR) | 2010-07-22 | — | — | WO | disclosed |
| WO-2010081783-A1 | NOVEL SPECIFIC INHIBITORS OF UBIQUITIN SPECIFIC PROTEASE 7, THE PHARMACEUTICAL COMPOSITIONS THEREOF AND THEIR THERAPEUTIC APPLICATIONS | HYBRIGENICS SA (FR) | 2010-07-22 | — | — | WO | disclosed |
| EP-2208725-A1 | Novel specific inhibitors of ubiquitin specific protease 7, the pharmaceutical compositions thereof and their therapeutic applications | Hybrigenics S.A. (FR) | 2010-07-21 | — | — | EP | disclosed |
| EP-2208725-A1 | Novel specific inhibitors of ubiquitin specific protease 7, the pharmaceutical compositions thereof and their therapeutic applications | Hybrigenics S.A. (FR) | 2010-07-21 | — | — | EP | disclosed |