SCHEMBL3712912

SCHEMBL3712912

Fc1cccc(C(Cl)Cl)c1

nearest known ligand 0.50

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
TSHR P16473 1/20 0.48
HDAC4 P56524 1/20 0.47
HDAC7 Q8WUI4 1/20 0.47
HDAC5 Q9UQL6 1/20 0.47
IDO1 P14902 1/20 0.47
TDO2 P48775 1/20 0.47
CES2 O00748 2/20 0.46
CES1 P23141 2/20 0.46
ACHE P22303 1/20 0.42
NFE2L2 Q16236 1/20 0.41
AOC3 Q16853 1/20 0.41
SLC6A2 P23975 1/20 0.39
SLC6A4 P31645 1/20 0.39
CNR2 P34972 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5520949 0.85 HDAC4 (0.47) HDAC4HDAC7HDAC5IDO1TDO2
SCHEMBL931961 0.81 ACHE (0.44) HDAC4HDAC7HDAC5IDO1TDO2
SCHEMBL30058998 0.81 ACHE (0.44) HDAC4HDAC7HDAC5IDO1TDO2
SCHEMBL4975530 0.81 ACHE (0.44) HDAC4HDAC7HDAC5IDO1TDO2
SCHEMBL27919275 0.81 CES2 (0.52) HDAC4HDAC7HDAC5IDO1TDO2
SCHEMBL212526 0.81 ACHE (0.44) HDAC4HDAC7HDAC5IDO1TDO2
SCHEMBL27878400 0.81 IDO1 (0.48) HDAC4HDAC7HDAC5IDO1TDO2
SCHEMBL631114 0.81 TSHR (0.61) TSHRHDAC4
SCHEMBL4078129 0.79 HDAC4 (0.50) HDAC4HDAC7HDAC5IDO1TDO2
Ammonia Solution, Strong SCHEMBL3996337 0.78 IDO1 (0.50) TSHRHDAC4HDAC7HDAC5IDO1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0657407-B1 Process for the preparation of 3-fluoro-4,6-dichlorotoluene BAYER AG (DE) 1997-12-10 EP claimed
US-5475164-A Process for preparing 3-fluoro-4,6-dichlorotoluene BAYER AKTIENGESELLSCHAFT (DE) 1995-12-12 US claimed
CN-115894373-A N-substituted benzylpyrazole derivatives as beta 2 Use of allosteric modulators, antagonists and agonists of the adrenergic receptor 常州大学 2023-04-04 CN disclosed
CN-109111463-A The manufacturing method of aromatic compound DIC株式会社 2019-01-01 CN disclosed
CN-108698982-A FLUORINE ATOM-CONTAINING COMPOUND AND USE THEREOF 日产化学工业株式会社 2018-10-23 CN disclosed
CN-105143190-B Substituted naphthyridine and quinoline compounds as MAO inhibitors 达特神经科学(开曼)有限公司 2017-08-18 CN disclosed
CN-104254525-B aromatic ring compound TAKEDA PHARMACEUTICAL CO.,LTD. (JP) 2016-05-25 CN disclosed
EP-2964646-A1 NOVEL PYRAZOL DERIVATIVES F. Hoffmann-La Roche AG (CH) 2016-01-13 EP disclosed
CN-105143190-A Substituted naphthyridine and quinoline compounds as MAO inhibitors DART NEUROSCIENCE LLC 2015-12-09 CN disclosed
CN-104254525-A Aromatic ring compound TAKEDA PHARMACEUTICAL 2014-12-31 CN disclosed
WO-2014135507-A1 NOVEL PYRAZOL DERIVATIVES F. HOFFMANN-LA ROCHE AG (CH) 2014-09-12 WO disclosed
EP-2396304-A1 TRIAZOLE AND IMIDAZOLE DERIVATIVES FOR USE AS TGR5 AGONISTS IN THE TREATMENT OF DIABETES AND OBESITY Exelixis, Inc. (US) 2011-12-21 EP disclosed
WO-2010093845-A1 TRIAZOLE AND IMIDAZOLE DERIVATIVES FOR USE AS TGR5 AGONISTS IN THE TREATMENT OF DIABETES AND OBESITY EXELIXIS, INC. (US) 2010-08-19 WO disclosed
EP-0420941-B1 PROCESS FOR PRODUCTION OF AROMATIC ALDOXIMES ALLIED SIGNAL INC (US) 1994-01-12 EP disclosed
EP-0420941-A1 PROCESS FOR PRODUCTION OF AROMATIC ALDOXIMES. ALLIED SIGNAL INC (US) 1991-04-10 EP disclosed
US-4922017-A Process for production of aromatic aldoximes ALLIED-SIGNAL INC. (US) 1990-05-01 US disclosed
WO-1989012623-A1 PROCESS FOR PRODUCTION OF AROMATIC ALDOXIMES ALLIED-SIGNAL INC. (US) 1989-12-28 WO disclosed
EP-0041672-B1 PROCESS FOR THE PREPARATION OF AROMATIC ALDEHYDES BAYER AG (DE) 1983-09-28 EP disclosed
EP-0041672-A1 Process for the preparation of aromatic aldehydes BAYER AG (DE) 1981-12-16 EP disclosed