Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 10/20 | 0.51 |
| ▸ | CA2 | P00918 | 6/20 | 0.51 |
| ▸ | CA9 | Q16790 | 6/20 | 0.51 |
| ▸ | CA12 | O43570 | 5/20 | 0.47 |
| ▸ | CA1 | P00915 | 5/20 | 0.47 |
| ▸ | MMP13 | P45452 | 4/20 | 0.44 |
| ▸ | ADAMTS4 | O75173 | 3/20 | 0.44 |
| ▸ | MMP14 | P50281 | 3/20 | 0.44 |
| ▸ | MMP1 | P03956 | 3/20 | 0.44 |
| ▸ | ADAMTS5 | Q9UNA0 | 2/20 | 0.44 |
| ▸ | MEP1B | Q16820 | 1/20 | 0.44 |
| ▸ | TARS1 | P26639 | 1/20 | 0.43 |
| ▸ | MMP9 | P14780 | 3/20 | 0.43 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.43 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.43 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.43 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.43 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.43 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.43 |
| ▸ | MMP3 | P08254 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16601950 | 0.80 | MMP2 (0.57) | MMP2CA2CA9CA12CA1 | |
| SCHEMBL10029051 | 0.79 | MMP2 (0.71) | MMP2CA2CA9CA12CA1 | |
| SCHEMBL569412 | 0.78 | MMP2 (0.56) | MMP2CA2CA9CA12CA1 | |
| SCHEMBL568567 | 0.78 | MMP2 (0.72) | MMP2CA2CA9CA12CA1 | |
| SCHEMBL569752 | 0.78 | MMP2 (0.72) | MMP2CA2CA9CA12CA1 | |
| SCHEMBL569306 | 0.75 | MMP2 (0.50) | MMP2CA2CA9CA12CA1 | |
| SCHEMBL569487 | 0.73 | MMP2 (0.50) | MMP2CA2CA9CA12CA1 | |
| SCHEMBL569308 | 0.73 | MMP2 (0.50) | MMP2CA2CA9CA12CA1 | |
| SCHEMBL7887510 | 0.73 | MMP9 (0.46) | MMP2CA2CA9CA12CA1 | |
| SCHEMBL569413 | 0.70 | MMP2 (0.48) | MMP2CA2CA9CA12CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2393495-A1 | CARJBAMOYLPHOSPHONATES AS INHIBITORS AND USES THEREOF | Yissum Research Development Company of the Hebrew University of Jerusalem, Ltd. (IL) | 2011-12-14 | — | — | EP | disclosed |
| WO-2010089752-A1 | CARJBAMOYLPHOSPHONATES AS INHIBITORS AND USES THEREOF | YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM, LTD. (IL) | 2010-08-12 | — | — | WO | disclosed |