Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | APEX1 | P27695 | 1/20 | 0.30 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
| ▸ | CASP6 | P55212 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3706115 | 0.87 | KDM1A (0.30) | MEN1KMT2ACRBNCYP1A2POLB | |
| SCHEMBL3707937 | 0.84 | MEN1 (0.31) | MEN1KMT2ACYP1A2POLBTSHR | |
| SCHEMBL3705812 | 0.80 | — | — | |
| SCHEMBL3028296 | 0.69 | OPRM1 (0.38) | MAPTMEN1KMT2ACRBNCYP1A2 | |
| SCHEMBL3832335 | 0.66 | ALDH1A1 (0.41) | MAPTMEN1KMT2AMAPK1 | |
| SCHEMBL11461558 | 0.63 | AKR1C1 (0.39) | MEN1KMT2A | |
| SCHEMBL3018057 | 0.61 | ALDH1A1 (0.36) | MAPTMEN1KMT2AMAPK1NPSR1 | |
| SCHEMBL3023013 | 0.59 | ALDH1A1 (0.37) | MAPTMEN1KMT2A | |
| SCHEMBL7894208 | 0.59 | ALDH1A1 (0.37) | MAPTMEN1KMT2A | |
| SCHEMBL3023010 | 0.59 | ALDH1A1 (0.37) | MAPTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2391603-A1 | AROYLAMINO - AND HETEROAROYLAMINO-SUBSTITUTED PIPERIDINES AS GLYT-1 INHIBITORS | F. Hoffmann-La Roche AG (CH) | 2011-12-07 | — | — | EP | disclosed |
| WO-2010086251-A1 | AROYLAMINO - AND HETEROAROYLAMINO-SUBSTITUTED PIPERIDINES AS GLYT-1 INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2010-08-05 | — | — | WO | disclosed |