Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 1/20 | 0.39 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.39 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.37 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.37 |
| ▸ | CDC7 | O00311 | 1/20 | 0.37 |
| ▸ | DBF4 | Q9UBU7 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | ACACB | O00763 | 1/20 | 0.36 |
| ▸ | ACACA | Q13085 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.36 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.36 |
| ▸ | CSF1R | P07333 | 1/20 | 0.36 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3714675 | 0.92 | PTGER4 (0.42) | CYP3A4CYP2D6CYP2C9CYP2C19CYP1A2 | |
| SCHEMBL3713715 | 0.91 | CYP19A1 (0.40) | CYP19A1CYP11B1CYP11B2PAX8ALDH1A1 | |
| SCHEMBL3711841 | 0.90 | CYP19A1 (0.42) | CYP19A1CYP11B1CYP11B2ALDH1A1HIF1A | |
| SCHEMBL3711328 | 0.90 | AIMP2 (0.39) | CYP19A1CYP11B1CYP11B2PAX8ALDH1A1 | |
| SCHEMBL3711913 | 0.89 | CYP19A1 (0.41) | CYP19A1CYP11B1CYP11B2ALDH1A1HIF1A | |
| SCHEMBL3712077 | 0.89 | ABL1 (0.39) | CYP19A1CYP11B1CYP11B2CYP3A4CYP2D6 | |
| SCHEMBL3709548 | 0.88 | ALDH1A1 (0.42) | CYP19A1CYP11B1CYP11B2CYP3A4CYP2D6 | |
| SCHEMBL13188255 | 0.88 | CYP11B1 (0.49) | CYP19A1CYP11B1CYP11B2CYP3A4CYP2D6 | |
| SCHEMBL3711200 | 0.88 | PRKD1 (0.41) | CYP19A1CYP11B1CYP11B2PAX8HIF1A | |
| SCHEMBL3714505 | 0.88 | PIK3CA (0.48) | CYP19A1CYP11B1CYP11B2CYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010100475-A1 | HYDROXAMIC ACID DERIVATIVES AS GRAM-NEGATIVE ANTIBACTERIAL AGENTS | ASTRAZENECA AB (SE) | 2010-09-10 | — | — | WO | disclosed |