Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 15/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 3/20 | 0.48 |
| ▸ | RECQL | P46063 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.47 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL424048 | 0.98 | HPGD (0.52) | HPGDALDH1A1SMN1; SMN2LMNAPOLB | |
| SCHEMBL426196 | 0.95 | SMN1; SMN2 (0.55) | HPGDALDH1A1SMN1; SMN2LMNAPOLB | |
| SCHEMBL425630 | 0.84 | PKM (0.54) | HPGDTSHRRECQLKMT2AL3MBTL1 | |
| SCHEMBL1661992 | 0.82 | GRM3 (0.48) | ALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL1661991 | 0.82 | GRM3 (0.48) | ALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL3713677 | 0.82 | HPGD (0.56) | HPGDALDH1A1LMNAPOLBTSHR | |
| SCHEMBL1661137 | 0.80 | PDK2 (0.46) | — | |
| SCHEMBL3778711 | 0.79 | HPGD (0.58) | HPGDALDH1A1TSHRRECQLCYP1A2 | |
| SCHEMBL14632588 | 0.79 | LMNA (0.41) | HPGDALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL1662640 | 0.79 | PDK2 (0.49) | NPC1GAARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2391625-A1 | NEW ADENOSINE RECEPTOR LIGANDS AND USES THEREOF | Domain Therapeutics (FR) | 2011-12-07 | — | — | EP | disclosed |
| WO-2010084425-A1 | NEW ADENOSINE RECEPTOR LIGANDS AND USES THEREOF | DOMAIN THERAPEUTICS (FR) | 2010-07-29 | — | — | WO | disclosed |