Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 16/20 | 0.54 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | STAT3 | P40763 | 1/20 | 0.37 |
| ▸ | STAT1 | P42224 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2118396 | 0.91 | TRPV1 (0.57) | TRPV1STAT3STAT1 | |
| SCHEMBL2118393 | 0.91 | TRPV1 (0.57) | TRPV1STAT3STAT1 | |
| SCHEMBL2117707 | 0.80 | TRPV1 (0.56) | TRPV1STAT3STAT1 | |
| SCHEMBL2117703 | 0.80 | TRPV1 (0.56) | TRPV1STAT3STAT1 | |
| SCHEMBL2118870 | 0.79 | TRPV1 (0.62) | TRPV1HDAC4HDAC6STAT3STAT1 | |
| SCHEMBL2118874 | 0.79 | TRPV1 (0.62) | TRPV1HDAC4HDAC6STAT3STAT1 | |
| SCHEMBL1686273 | 0.74 | TRPV1 (0.72) | TRPV1 | |
| SCHEMBL1686272 | 0.74 | TRPV1 (0.72) | TRPV1 | |
| SCHEMBL2120590 | 0.72 | TRPV1 (0.58) | TRPV1STAT3STAT1 | |
| SCHEMBL2120127 | 0.71 | TRPV1 (0.52) | TRPV1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2393788-A1 | ISOXAZOLE-5-CARBOXAMIDE DERIVATIVES | N.V. Organon (NL) | 2011-12-14 | — | — | EP | claimed |
| WO-2010089297-A1 | ISOXAZOLE-5-CARBOXAMIDE DERIVATIVES | N.V. ORGANON (NL) | 2010-08-12 | — | — | WO | claimed |
| EP-2393788-A1 | ISOXAZOLE-5-CARBOXAMIDE DERIVATIVES | N.V. Organon (NL) | 2011-12-14 | — | — | EP | disclosed |
| WO-2010089297-A1 | ISOXAZOLE-5-CARBOXAMIDE DERIVATIVES | N.V. ORGANON (NL) | 2010-08-12 | — | — | WO | disclosed |