Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 16/20 | 0.56 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.45 |
| ▸ | STAT3 | P40763 | 1/20 | 0.43 |
| ▸ | STAT1 | P42224 | 1/20 | 0.43 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2117707 | 1.00 | TRPV1 (0.56) | TRPV1GABRA5STAT3STAT1GPBAR1 | |
| SCHEMBL10039159 | 0.89 | GABRA5 (0.48) | TRPV1GABRA5GPBAR1 | |
| SCHEMBL2120123 | 0.89 | TRPV1 (0.52) | TRPV1GABRA5 | |
| SCHEMBL2120127 | 0.89 | TRPV1 (0.52) | TRPV1GABRA5 | |
| SCHEMBL2118393 | 0.88 | TRPV1 (0.57) | TRPV1STAT3STAT1GPBAR1 | |
| SCHEMBL2118396 | 0.88 | TRPV1 (0.57) | TRPV1STAT3STAT1GPBAR1 | |
| SCHEMBL2117857 | 0.86 | TRPV1 (0.44) | TRPV1GABRA5 | |
| SCHEMBL2117862 | 0.86 | TRPV1 (0.44) | TRPV1GABRA5 | |
| SCHEMBL2118870 | 0.82 | TRPV1 (0.62) | TRPV1GABRA5STAT3STAT1 | |
| SCHEMBL2118874 | 0.82 | TRPV1 (0.62) | TRPV1GABRA5STAT3STAT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120095002-A1 | ISOXAZOLE-5-CARBOXAMIDE DERIVATIVES | N.V. ORGANON (NL) | 2012-04-19 | — | — | US | claimed |
| US-20120095002-A1 | ISOXAZOLE-5-CARBOXAMIDE DERIVATIVES | N.V. ORGANON (NL) | 2012-04-19 | — | — | US | disclosed |
| US-20120095002-A1 | ISOXAZOLE-5-CARBOXAMIDE DERIVATIVES | N.V. ORGANON (NL) | 2012-04-19 | — | — | US | disclosed |
| WO-2010089297-A1 | ISOXAZOLE-5-CARBOXAMIDE DERIVATIVES | N.V. ORGANON (NL) | 2010-08-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120095002-A1 | ISOXAZOLE-5-CARBOXAMIDE DERIVATIVES | TRPV1, TRPV5, P2RX5 | TRPV1 1/4885GABRA5 47/4885STAT3 2125/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.