Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 4/20 | 0.52 |
| ▸ | GABRA5 | P31644 | 8/20 | 0.46 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2120123 | 1.00 | TRPV1 (0.52) | TRPV1GABRA5GRIN2BLMNAGABRA1 | |
| SCHEMBL10039159 | 0.91 | GABRA5 (0.48) | TRPV1GABRA5GABRA1SMN1; SMN2 | |
| SCHEMBL2117707 | 0.89 | TRPV1 (0.56) | TRPV1GABRA5 | |
| SCHEMBL2117703 | 0.89 | TRPV1 (0.56) | TRPV1GABRA5 | |
| SCHEMBL2118396 | 0.78 | TRPV1 (0.57) | TRPV1 | |
| SCHEMBL2118393 | 0.78 | TRPV1 (0.57) | TRPV1 | |
| SCHEMBL10039170 | 0.76 | GABRA5 (0.43) | GABRA5GABRA1SMN1; SMN2ALDH1A1 | |
| SCHEMBL2117773 | 0.76 | TRPV1 (0.55) | TRPV1GABRA5LMNAL3MBTL1 | |
| SCHEMBL2117862 | 0.75 | TRPV1 (0.44) | TRPV1GABRA5GABRA1 | |
| SCHEMBL2117857 | 0.75 | TRPV1 (0.44) | TRPV1GABRA5GABRA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120095002-A1 | ISOXAZOLE-5-CARBOXAMIDE DERIVATIVES | N.V. ORGANON (NL) | 2012-04-19 | — | — | US | claimed |
| US-20120095002-A1 | ISOXAZOLE-5-CARBOXAMIDE DERIVATIVES | N.V. ORGANON (NL) | 2012-04-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120095002-A1 | ISOXAZOLE-5-CARBOXAMIDE DERIVATIVES | TRPV1, TRPV5, P2RX5 | TRPV1 1/4885GABRA5 47/4885GRIN2B 326/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.