Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHKA | P35790 | 1/20 | 0.50 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | KDM6B | O15054 | 1/20 | 0.48 |
| ▸ | KDM5C | P41229 | 1/20 | 0.48 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.48 |
| ▸ | KDM2A | Q9Y2K7 | 1/20 | 0.48 |
| ▸ | KDM3A | Q9Y4C1 | 1/20 | 0.48 |
| ▸ | WNK1 | Q9H4A3 | 1/20 | 0.47 |
| ▸ | ACACB | O00763 | 1/20 | 0.47 |
| ▸ | JMJD6 | Q6NYC1 | 1/20 | 0.46 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.44 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.44 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3710215 | 0.99 | CHKA (0.49) | CHKAHDAC1KDM4EKDM6BKDM5C | |
| SCHEMBL3715041 | 0.91 | HDAC1 (0.52) | HDAC1KDM4EKDM6BKDM5CKDM4C | |
| SCHEMBL13187716 | 0.86 | HDAC1 (0.55) | HDAC1ACACBHDAC3HDAC2HDAC6 | |
| SCHEMBL3715176 | 0.86 | HDAC1 (0.49) | HDAC1WNK1 | |
| SCHEMBL13188804 | 0.85 | HDAC1 (0.54) | HDAC1CHRM1MCHR1HDAC3HDAC2 | |
| SCHEMBL13188330 | 0.83 | HDAC1 (0.56) | CHKAHDAC1KDM4EKDM6BKDM5C | |
| SCHEMBL3714455 | 0.83 | MRGPRX4 (0.47) | HDAC1WNK1ACACBKDM5BHRH3 | |
| SCHEMBL3713492 | 0.81 | HDAC1 (0.52) | HDAC1KDM4EKDM6BKDM5CKDM4C | |
| SCHEMBL3714564 | 0.81 | KDM4E (0.49) | HDAC1KDM4EKDM6BKDM5CKDM4C | |
| SCHEMBL3714518 | 0.80 | MRGPRX4 (0.55) | HDAC1WNK1HRH3SMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010100475-A1 | HYDROXAMIC ACID DERIVATIVES AS GRAM-NEGATIVE ANTIBACTERIAL AGENTS | ASTRAZENECA AB (SE) | 2010-09-10 | — | — | WO | disclosed |
| WO-2010100475-A1 | HYDROXAMIC ACID DERIVATIVES AS GRAM-NEGATIVE ANTIBACTERIAL AGENTS | ASTRAZENECA AB (SE) | 2010-09-10 | — | — | WO | disclosed |