Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.55 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.53 |
| ▸ | KDM1A | O60341 | 1/20 | 0.53 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.48 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.48 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.48 |
| ▸ | UBA2 | Q9UBT2 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.47 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.47 |
| ▸ | WNK1 | Q9H4A3 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13188330 | 0.92 | HDAC1 (0.56) | HDAC1KDM1ASMN1; SMN2MAPK1ALDH1A1 | |
| SCHEMBL3715041 | 0.89 | HDAC1 (0.52) | HDAC1KDM1ASMN1; SMN2MAPK1 | |
| SCHEMBL3711902 | 0.89 | HDAC1 (0.67) | HDAC1KDM1AADAMTS4POLBCACNA1B | |
| SCHEMBL3714455 | 0.81 | MRGPRX4 (0.47) | MRGPRX4HDAC1KDM1ASMN1; SMN2MAPK1 | |
| SCHEMBL3712555 | 0.80 | HDAC1 (0.62) | MRGPRX4HDAC1ADAMTS4SMN1; SMN2HPGD | |
| SCHEMBL3714667 | 0.80 | HDAC1 (0.60) | MRGPRX4HDAC1KDM1ASMN1; SMN2POLB | |
| SCHEMBL3721428 | 0.80 | KDM4E (0.52) | MRGPRX4HDAC1KDM1AADAMTS4SMN1; SMN2 | |
| SCHEMBL3713872 | 0.80 | CHKA (0.50) | HDAC1SMN1; SMN2ALDH1A1LMNAMAPT | |
| SCHEMBL3713492 | 0.80 | HDAC1 (0.52) | MRGPRX4HDAC1KDM1AALDH1A1 | |
| SCHEMBL3710215 | 0.79 | CHKA (0.49) | HDAC1SMN1; SMN2LMNAMAPTHRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010100475-A1 | HYDROXAMIC ACID DERIVATIVES AS GRAM-NEGATIVE ANTIBACTERIAL AGENTS | ASTRAZENECA AB (SE) | 2010-09-10 | — | — | WO | disclosed |
| WO-2010100475-A1 | HYDROXAMIC ACID DERIVATIVES AS GRAM-NEGATIVE ANTIBACTERIAL AGENTS | ASTRAZENECA AB (SE) | 2010-09-10 | — | — | WO | disclosed |