Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 4/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | KDM1A | O60341 | 2/20 | 0.49 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.49 |
| ▸ | JAK2 | O60674 | 1/20 | 0.47 |
| ▸ | JAK3 | P52333 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | KDM6B | O15054 | 1/20 | 0.46 |
| ▸ | KDM5C | P41229 | 1/20 | 0.46 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.46 |
| ▸ | KDM2A | Q9Y2K7 | 1/20 | 0.46 |
| ▸ | KDM3A | Q9Y4C1 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13188330 | 0.93 | HDAC1 (0.56) | HDAC1MAPK1SMN1; SMN2KDM1AMAPKAPK2 | |
| SCHEMBL3714455 | 0.92 | MRGPRX4 (0.47) | HDAC1MAPK1SMN1; SMN2KDM1AMAPKAPK2 | |
| SCHEMBL3713872 | 0.91 | CHKA (0.50) | HDAC1SMN1; SMN2KDM4EKDM6BKDM5C | |
| SCHEMBL3713492 | 0.90 | HDAC1 (0.52) | HDAC1KDM1AKDM4EKDM6BKDM5C | |
| SCHEMBL3710215 | 0.90 | CHKA (0.49) | HDAC1SMN1; SMN2KDM4EKDM6BKDM5C | |
| SCHEMBL3714518 | 0.89 | MRGPRX4 (0.55) | HDAC1MAPK1SMN1; SMN2KDM1A | |
| SCHEMBL3713942 | 0.89 | HRH3 (0.43) | HDAC1MAPK1SMN1; SMN2KDM1AMAPKAPK2 | |
| SCHEMBL3715159 | 0.87 | HDAC1 (0.65) | HDAC1KDM1AMAPKAPK2 | |
| SCHEMBL3717935 | 0.85 | MAPK1 (0.50) | MAPK1SMN1; SMN2KMT2A | |
| SCHEMBL3711313 | 0.85 | MAPK1 (0.49) | MAPK1SMN1; SMN2JAK2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010100475-A1 | HYDROXAMIC ACID DERIVATIVES AS GRAM-NEGATIVE ANTIBACTERIAL AGENTS | ASTRAZENECA AB (SE) | 2010-09-10 | — | — | WO | disclosed |