Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 1/20 | 0.34 |
| ▸ | DPP4 | P27487 | 1/20 | 0.34 |
| ▸ | BTK | Q06187 | 1/20 | 0.33 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.31 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.31 |
| ▸ | RELA | Q04206 | 1/20 | 0.31 |
| ▸ | CCR5 | P51681 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22308421 | 0.93 | DPP4 (0.33) | DPP4HSD11B1NFKB1NFKB2RELA | |
| SCHEMBL14327679 | 0.87 | CHRM2 (0.34) | DPP4HSD11B1NFKB1NFKB2RELA | |
| SCHEMBL13052389 | 0.87 | CHRM2 (0.34) | DPP4HSD11B1NFKB1NFKB2RELA | |
| SCHEMBL13052392 | 0.86 | NFKB1 (0.32) | DPP4NFKB1NFKB2RELACCR5 | |
| SCHEMBL27510109 | 0.83 | EPHX1 (0.39) | EPHX1DPP4HSD11B1GAA | |
| SCHEMBL23328804 | 0.82 | NFKB1 (0.36) | HSD11B1NFKB1NFKB2RELA | |
| SCHEMBL2822608 | 0.82 | HDAC6 (0.33) | NFKB1NFKB2RELA | |
| SCHEMBL7025316 | 0.81 | EPHX2 (0.36) | EPHX1BTKGAA | |
| SCHEMBL992260 | 0.80 | — | — | |
| SCHEMBL13769592 | 0.80 | EPHX1 (0.37) | EPHX1DPP4BTKHSD11B1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010108059-A1 | SUBSTITUTED PYRIMIDINE DERIVATIVES AS ANTAGONISTS OF THE HISTAMINE H4 RECEPTOR | INCYTE CORPORATION (US) | 2010-09-23 | — | — | WO | disclosed |