Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARD | Q03181 | 1/20 | 0.48 |
| ▸ | DRD3 | P35462 | 1/20 | 0.44 |
| ▸ | BLM | P54132 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.43 |
| ▸ | CA12 | O43570 | 3/20 | 0.43 |
| ▸ | CA2 | P00918 | 3/20 | 0.43 |
| ▸ | CA9 | Q16790 | 3/20 | 0.43 |
| ▸ | CASP2 | P42575 | 2/20 | 0.43 |
| ▸ | F13A1 | P00488 | 2/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.43 |
| ▸ | CA4 | P22748 | 2/20 | 0.43 |
| ▸ | CA6 | P23280 | 2/20 | 0.43 |
| ▸ | CA5A | P35218 | 2/20 | 0.43 |
| ▸ | THPO | P40225 | 2/20 | 0.43 |
| ▸ | CA7 | P43166 | 2/20 | 0.43 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.43 |
| ▸ | CA5B | Q9Y2D0 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9203519 | 0.92 | PPARD (0.52) | PPARDCYP1A2CA12CA2CA9 | |
| SCHEMBL491800 | 0.86 | PPARD (0.62) | PPARDCA12CA2CA9MEN1 | |
| SCHEMBL3341956 | 0.85 | PPARD (0.52) | PPARDCA12CA2CA9MEN1 | |
| SCHEMBL2816261 | 0.84 | PPARD (0.42) | PPARDCYP1A2CA12CA2CA9 | |
| SCHEMBL371461 | 0.81 | BLM (0.47) | DRD3BLMCYP1A2CA12CA2 | |
| SCHEMBL30604707 | 0.80 | PPARD (0.57) | PPARDCA12CA2CA9MEN1 | |
| Hydrochloric Acid SCHEMBL5595849 | 0.80 | S1PR2 (0.58) | PPARDCA12CA2CA9TSHR | |
| SCHEMBL491488 | 0.80 | PPARD (0.54) | PPARDBLMCYP1A2THPOMEN1 | |
| SCHEMBL14768680 | 0.79 | PPARD (0.46) | PPARDCA12CA2CA9MEN1 | |
| SCHEMBL15532056 | 0.79 | PPARD (0.65) | PPARDCA12CA2CA9MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2408790-A1 | METHODS FOR THE PREPARATION OF [2-(8,9-DIOXO-2,6-DIAZABICYCLO[5.2.0]NON-1(7)-EN-2-YL)ETHYL]PHOSPHONIC ACID AND PRECURSORS THEREOF | Wyeth LLC (US) | 2012-01-25 | — | — | EP | claimed |
| WO-2010108063-A1 | METHODS FOR THE PREPARATION OF [2-(8,9-DIOXO-2,6-DIAZABICYCLO[5.2.0]NON-1(7)-EN-2-YL)ETHYL]PHOSPHONIC ACID AND PRECURSORS THEREOF | WYETH LLC (US) | 2010-09-23 | — | — | WO | claimed |
| US-20120116074-A1 | METHODS FOR THE PREPARATION OF [2-(8,9-DIOXO-2,6-DIAZABICYCLO[5.2.0]NON-1(7)-EN-2-YL)ETHYL]PHOSPHONIC ACID AND PRECURSORS THEREOF | CULLEN THOMAS GERARD (US) | 2012-05-10 | — | — | US | disclosed |
| US-20120116074-A1 | METHODS FOR THE PREPARATION OF [2-(8,9-DIOXO-2,6-DIAZABICYCLO[5.2.0]NON-1(7)-EN-2-YL)ETHYL]PHOSPHONIC ACID AND PRECURSORS THEREOF | CULLEN THOMAS GERARD (US) | 2012-05-10 | — | — | US | disclosed |
| EP-2408790-A1 | METHODS FOR THE PREPARATION OF [2-(8,9-DIOXO-2,6-DIAZABICYCLO[5.2.0]NON-1(7)-EN-2-YL)ETHYL]PHOSPHONIC ACID AND PRECURSORS THEREOF | Wyeth LLC (US) | 2012-01-25 | — | — | EP | disclosed |
| WO-2010108063-A1 | METHODS FOR THE PREPARATION OF [2-(8,9-DIOXO-2,6-DIAZABICYCLO[5.2.0]NON-1(7)-EN-2-YL)ETHYL]PHOSPHONIC ACID AND PRECURSORS THEREOF | WYETH LLC (US) | 2010-09-23 | — | — | WO | disclosed |
| EP-2195031-A1 | COMPOSITIONS AND METHODS EMPLOYING NMDA ANTAGONISTS FOR ACHIEVING AN ANESTHETIC-SPARING EFFECT | Wyeth a Corporation of the State of Delaware (US) | 2010-06-16 | — | — | EP | disclosed |
| US-20090061024-A1 | COMPOSITIONS AND METHODS EMPLOYING NMDA ANTAGONISTS FOR ACHIEVING AN ANESTHETIC-SPARING EFFECT | WYETH (US) | 2009-03-05 | — | — | US | disclosed |
| US-20090061024-A1 | COMPOSITIONS AND METHODS EMPLOYING NMDA ANTAGONISTS FOR ACHIEVING AN ANESTHETIC-SPARING EFFECT | WYETH (US) | 2009-03-05 | — | — | US | disclosed |
| WO-2009029618-A1 | COMPOSITIONS AND METHODS EMPLOYING NMDA ANTAGONISTS FOR ACHIEVING AN ANESTHETIC-SPARING EFFECT | WYETH (US) | 2009-03-05 | — | — | WO | disclosed |
| US-20080114165-A1 | Methods for the Preparation of {2-[(8,9)-Dioxo-2,6-diaza-bicyclo[5.2.0]-non-1(7)-en-2-yl]ethyl} Phosphonic Acid and Esters Thereof | WYETH (US) | 2008-05-15 | — | — | US | disclosed |
| US-20080114165-A1 | Methods for the Preparation of {2-[(8,9)-Dioxo-2,6-diaza-bicyclo[5.2.0]-non-1(7)-en-2-yl]ethyl} Phosphonic Acid and Esters Thereof | WYETH (US) | 2008-05-15 | — | — | US | disclosed |
| US-20080114165-A1 | Methods for the Preparation of {2-[(8,9)-Dioxo-2,6-diaza-bicyclo[5.2.0]-non-1(7)-en-2-yl]ethyl} Phosphonic Acid and Esters Thereof | WYETH (US) | 2008-05-15 | — | — | US | disclosed |
| US-7345032-B2 | alkylation of 1,3-diaminopropane or addition to diethyl vinylphosphonate, to form N-(3-aminopropyl)aminoethanephosphonic acid diethyl ester, which is condensed with a squarate compound to give drugs used as N-methyl-D-aspartic acid (NMDA) antagonists | WYETH (US) | 2008-03-18 | — | — | US | disclosed |
| US-7345032-B2 | alkylation of 1,3-diaminopropane or addition to diethyl vinylphosphonate, to form N-(3-aminopropyl)aminoethanephosphonic acid diethyl ester, which is condensed with a squarate compound to give drugs used as N-methyl-D-aspartic acid (NMDA) antagonists | WYETH (US) | 2008-03-18 | — | — | US | disclosed |
| US-7345032-B2 | alkylation of 1,3-diaminopropane or addition to diethyl vinylphosphonate, to form N-(3-aminopropyl)aminoethanephosphonic acid diethyl ester, which is condensed with a squarate compound to give drugs used as N-methyl-D-aspartic acid (NMDA) antagonists | WYETH (US) | 2008-03-18 | — | — | US | disclosed |
| EP-1675863-A2 | METHOD FOR THE PREPARATION OF {2-[8,9-DIOXO-2,6-DIAZA-BICYCLO[5.2.0]-NON-1(7)-EN-2-YL]ETHYL} PHOSPHONIC ACID AND ESTERS THEREOF | Wyeth (US) | 2006-07-05 | — | — | EP | disclosed |
| WO-2005040176-A2 | METHODS FOR THE PREPARATION OF {2-[8,9-DIOXO-2,6-DIAZA-BICYCLO[5.2.0]-NON-1(7)-EN-2-YL]ETHYL}PHOSPHONIC ACID AND ESTERS THEREOF | WYETH (US) | 2005-05-06 | — | — | WO | disclosed |
| US-20050090470-A1 | Methods for the preparation of {2-[(8,9)-dioxo-2,6-diaza-bicyclo[5.2.0]-non-1(7)-en-2-yl[ethyl} phosphonic acid and esters thereof | WYETH (US) | 2005-04-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050090470-A1 | Methods for the preparation of {2-[(8,9)-dioxo-2,6-diaza-bicyclo[5.2.0]-non-1(7)-en-2-yl[ethyl} phosphonic acid and esters thereof | PHOSPHO1, ENPP1, ENO1 | PPARD 824/4885DRD3 3877/4885BLM 3060/4885 |
| US-20090061024-A1 | COMPOSITIONS AND METHODS EMPLOYING NMDA ANTAGONISTS FOR ACHIEVING AN ANESTHETIC-SPARING EFFECT | GRIN3A, GRIN1, GRIN2A | PPARD 894/4885DRD3 1206/4885BLM 3816/4885 |
| US-20120116074-A1 | METHODS FOR THE PREPARATION OF [2-(8,9-DIOXO-2,6-DIAZABICYCLO[5.2.0]NON-1(7)-EN-2-YL)ETHYL]PHOSPHONIC ACID AND PRECURSORS THEREOF | DERA, ENO1, PPIP5K2 | PPARD 866/4885DRD3 4459/4885BLM 4337/4885 |
| US-20080114165-A1 | Methods for the Preparation of {2-[(8,9)-Dioxo-2,6-diaza-bicyclo[5.2.0]-non-1(7)-en-2-yl]ethyl} Phosphonic Acid and Esters Thereof | PHOSPHO1, ENPP1, ENO1 | PPARD 805/4885DRD3 3811/4885BLM 3110/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.