Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | AKT1 | P31749 | 2/20 | 0.44 |
| ▸ | AKT2 | P31751 | 2/20 | 0.44 |
| ▸ | NSD2 | O96028 | 1/20 | 0.44 |
| ▸ | NAMPT | P43490 | 2/20 | 0.44 |
| ▸ | DHODH | Q02127 | 3/20 | 0.43 |
| ▸ | GALR3 | O60755 | 1/20 | 0.43 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.43 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.42 |
| ▸ | SUCNR1 | Q9BXA5 | 1/20 | 0.41 |
| ▸ | TACR3 | P29371 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12133553 | 0.85 | NAMPT (0.54) | TP53LMNAAKT1AKT2NAMPT | |
| SCHEMBL3781331 | 0.84 | SUCNR1 (0.51) | AKT1AKT2DHODHRXFP1SUCNR1 | |
| SCHEMBL3788803 | 0.81 | KMT2A (0.44) | TP53LMNAAKT1AKT2NAMPT | |
| SCHEMBL3787154 | 0.81 | DHODH (0.46) | TP53LMNADHODHRXFP1TACR3 | |
| SCHEMBL28083091 | 0.81 | TOP1 (0.51) | LMNAAKT1AKT2MEN1KMT2A | |
| SCHEMBL1349852 | 0.80 | AKT1 (0.48) | TP53LMNAAKT1AKT2NAMPT | |
| SCHEMBL27653760 | 0.80 | MEN1 (0.65) | LMNAAKT1AKT2DHODHMEN1 | |
| SCHEMBL3788617 | 0.79 | TP53 (0.42) | TP53LMNAAKT1AKT2NAMPT | |
| SCHEMBL12803747 | 0.79 | KMT2A (0.47) | TP53LMNARXFP1TACR3KMT2A | |
| SCHEMBL3790086 | 0.79 | TP53 (0.44) | TP53LMNAAKT1AKT2DHODH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2391623-A1 | INHIBITORS OF AKT ACTIVITY | Merck Sharp & Dohme Corp. (US) | 2011-12-07 | — | — | EP | disclosed |
| WO-2010088177-A1 | INHIBITORS OF AKT ACTIVITY | MERCK SHARP & DOHME CORP. (US) | 2010-08-05 | — | — | WO | disclosed |