Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.44 |
| ▸ | MMP2 | P08253 | 1/20 | 0.43 |
| ▸ | MMP8 | P22894 | 1/20 | 0.43 |
| ▸ | MMP13 | P45452 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13187783 | 0.94 | KMT2A (0.53) | KMT2AHDAC1HDAC3HDAC2HDAC8 | |
| SCHEMBL3714327 | 0.93 | KMT2A (0.50) | KMT2A | |
| SCHEMBL13188642 | 0.86 | KMT2A (0.54) | KMT2A | |
| SCHEMBL3718827 | 0.80 | HIF1A (0.42) | HDAC1HDAC3HDAC2HDAC8HDAC6 | |
| SCHEMBL3711052 | 0.78 | MAPK1 (0.48) | KMT2AMMP2MMP8MMP13 | |
| SCHEMBL3711870 | 0.78 | HRH3 (0.44) | — | |
| SCHEMBL3715055 | 0.78 | HIF1A (0.43) | HDAC1HDAC3HDAC2HDAC8HDAC6 | |
| SCHEMBL3714232 | 0.77 | HDAC1 (0.54) | HDAC1HDAC3HDAC2HDAC8HDAC6 | |
| SCHEMBL13187707 | 0.77 | HDAC1 (0.48) | KMT2AHDAC1HDAC3HDAC2HDAC8 | |
| SCHEMBL3715159 | 0.74 | HDAC1 (0.65) | HDAC1HDAC3HDAC2HDAC8HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010100475-A1 | HYDROXAMIC ACID DERIVATIVES AS GRAM-NEGATIVE ANTIBACTERIAL AGENTS | ASTRAZENECA AB (SE) | 2010-09-10 | — | — | WO | disclosed |