Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 4/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 2/20 | 0.41 |
| ▸ | CA2 | P00918 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA7 | P43166 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.41 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.40 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31435350 | 0.89 | MAPK1 (0.56) | MAPK1KDM4EL3MBTL1MAPTALDH1A1 | |
| SCHEMBL9446824 | 0.86 | MAPK1 (0.53) | MAPK1KDM4EL3MBTL1MAPTALDH1A1 | |
| SCHEMBL28396260 | 0.82 | HCAR3 (0.50) | MAPTALDH1A1HCAR3 | |
| SCHEMBL3715299 | 0.81 | HCAR3 (0.49) | MAPTALDH1A1HCAR3 | |
| SCHEMBL204895 | 0.80 | MAPK1 (0.61) | MAPK1KDM4EL3MBTL1MAPTALDH1A1 | |
| SCHEMBL1441132 | 0.80 | MAPK1 (0.61) | MAPK1KDM4EL3MBTL1MAPTALDH1A1 | |
| SCHEMBL29695095 | 0.80 | MAPK1 (0.61) | MAPK1KDM4EL3MBTL1MAPTALDH1A1 | |
| SCHEMBL1439028 | 0.79 | MAPK1 (0.59) | MAPK1KDM4EL3MBTL1MAPTALDH1A1 | |
| SCHEMBL480126 | 0.79 | MAPK1 (0.59) | MAPK1KDM4EL3MBTL1MAPTALDH1A1 | |
| SCHEMBL198840 | 0.79 | MAPK1 (0.59) | MAPK1KDM4EL3MBTL1MAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2391617-A1 | AZETIDINES AS HISTAMINE H3 RECEPTOR ANTAGONISTS | Evotec AG (DE) | 2011-12-07 | — | — | EP | disclosed |
| WO-2010086403-A1 | AZETIDINES AS HISTAMINE H3 RECEPTOR ANTAGONISTS | EVOTEC NEUROSCIENCES GMBH (DE) | 2010-08-05 | — | — | WO | disclosed |