SCHEMBL3715209

SCHEMBL3715209

CSc1cc(C(F)(C(F)(F)F)C(F)(F)C(F)(F)F)cc(Cl)c1NC(=O)c1ccc(C#N)c(NC(=O)c2ccc(C#N)cc2C)c1

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 7/20 0.44
MEN1 O00255 5/20 0.44
CYP1A2 P05177 1/20 0.43
CYP3A4 P08684 1/20 0.43
CYP2D6 P10635 1/20 0.43
CYP2C9 P11712 1/20 0.43
CYP2C19 P33261 1/20 0.43
L3MBTL1 Q9Y468 2/20 0.42
PDK1 Q15118 1/20 0.34
PDK2 Q15119 1/20 0.34
PDK3 Q15120 1/20 0.34
PDK4 Q16654 1/20 0.34
RXFP1 Q9HBX9 2/20 0.34
NR1H4 Q96RI1 1/20 0.33
LRRK2 Q5S007 1/20 0.33
SMN1; SMN2 Q16637 4/20 0.32
PRSS12 P56730 1/20 0.32
ALDH1A1 P00352 5/20 0.32
HPGD P15428 2/20 0.32
LMNA P02545 2/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3703139 0.93 KMT2A (0.39) KMT2AMEN1CYP1A2CYP3A4CYP2D6
SCHEMBL29360734 0.93 KMT2A (0.39) KMT2AMEN1CYP1A2CYP3A4CYP2D6
SCHEMBL3700196 0.91 KMT2A (0.38) KMT2AMEN1CYP1A2CYP3A4CYP2D6
SCHEMBL29362569 0.91 KMT2A (0.38) KMT2AMEN1CYP1A2CYP3A4CYP2D6
SCHEMBL29362173 0.89 KMT2A (0.36) KMT2AMEN1CYP1A2CYP3A4CYP2D6
SCHEMBL3699644 0.89 KMT2A (0.36) KMT2AMEN1CYP1A2CYP3A4CYP2D6
SCHEMBL298875 0.89 KMT2A (0.40) KMT2AMEN1CYP1A2CYP3A4CYP2D6
SCHEMBL29360338 0.89 KMT2A (0.40) KMT2AMEN1CYP1A2CYP3A4CYP2D6
SCHEMBL289051 0.88 RXFP1 (0.39) KMT2AMEN1CYP1A2CYP3A4CYP2D6
SCHEMBL31560030 0.87 RXFP1 (0.38) KMT2AMEN1CYP1A2CYP3A4CYP2D6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-106242998-B Use of 4-cyano-3-benzoylamino-N-phenyl-benzamides in pesticides 先正达参股股份有限公司 2021-11-05 CN disclosed
EP-2427427-B1 4-CYANO-3-BENZOYLAMINO-N-PHENYL-BENZAMIDES FOR USE IN PEST CONTROL SYNGENTA PARTICIPATIONS AG (CH) 2013-12-25 EP disclosed
WO-2013092942-A1 USE OF AMINOBENZAMIDE DERIVATIVES FOR CONTROLLING ANIMAL PARASITES SYNGENTA PARTICIPATIONS AG (CH) 2013-06-27 WO disclosed
US-8431514-B2 4-cyano-3-benzoylamino-N-phenyl-benzamides for use in pest control SYNGENTA CROP PROTECTION LLC (US) 2013-04-30 US disclosed
US-20120122975-A1 4-CYANO-3-BENZOYLAMINO-N-PHENYL-BENZAMIDES FOR USE IN PEST CONTROL SYNGENTA CROP PROTECTION LLC (US) 2012-05-17 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120122975-A1 4-CYANO-3-BENZOYLAMINO-N-PHENYL-BENZAMIDES FOR USE IN PEST CONTROL NISCH, AADAC, ACHE KMT2A 901/4885MEN1 4616/4885CYP1A2 327/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.