Isorhamnetin

Isorhamnetin

SCHEMBL3715283

COc1cc(-c2oc3cc(O)cc(O)c3c(=O)c2O)ccc1O.O=c1c(O)c(-c2ccc(O)c(O)c2)oc2cc(O)cc(O)c12

nearest known ligand 0.93

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 8/20 0.93
KMT2A Q03164 8/20 0.93
CYP1A2 P05177 6/20 0.93
CYP1A1 P04798 5/20 0.93
CYP1B1 Q16678 5/20 0.93
IPMK Q8NFU5 4/20 0.93
IP6K2 Q9UHH9 4/20 0.93
XDH P47989 4/20 0.93
CA12 O43570 3/20 0.93
CA2 P00918 3/20 0.93
PPARG P37231 3/20 0.93
CA7 P43166 3/20 0.93
CA4 P22748 2/20 0.93
NOX4 Q9NPH5 3/20 0.80
KDM4E B2RXH2 6/20 0.79
HSD17B10 Q99714 6/20 0.79
CYP3A4 P08684 5/20 0.79
MAPT P10636 5/20 0.79
RECQL P46063 4/20 0.79
TP53 P04637 4/20 0.79

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Isorhamnetin SCHEMBL29390102 0.96 MEN1 (1.00) MEN1KMT2ACYP1A2CYP1A1CYP1B1
Isorhamnetin SCHEMBL29377152 0.96 MEN1 (1.00) MEN1KMT2ACYP1A2CYP1A1CYP1B1
Isorhamnetin SCHEMBL19235 0.96 MEN1 (1.00) MEN1KMT2ACYP1A2CYP1A1CYP1B1
Isorhamnetin SCHEMBL30385934 0.96 MEN1 (1.00) MEN1KMT2ACYP1A2CYP1A1CYP1B1
Isorhamnetin SCHEMBL28182051 0.93 MEN1 (0.93) MEN1KMT2ACYP1A2CYP1A1CYP1B1
Quercetin SCHEMBL11149166 0.92 MEN1 (0.90) MEN1KMT2ACYP1A2CYP1A1CYP1B1
SCHEMBL890990 0.89 NOX4 (1.00) MEN1KMT2ACYP1A2CYP1A1CYP1B1
Tamarixetin SCHEMBL892776 0.89 CYP1A2 (1.00) MEN1KMT2ACYP1A2CYP1A1CYP1B1
SCHEMBL3211188 0.89 MEN1 (0.86) MEN1KMT2ACYP1A2CYP1A1CYP1B1
SCHEMBL31408172 0.89 NOX4 (1.00) MEN1KMT2ACYP1A2CYP1A1CYP1B1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2459217-A1 REDUCTION OF IN VITRO GENOTOXICITY OF POLLEN EXTRACTS BY REMOVAL OF FLAVONOIDS Stallergenes S.A. (FR) 2012-06-06 EP disclosed
WO-2010139809-A1 REDUCTION OF IN VITRO GENOTOXICITY OF POLLEN EXTRACTS BY REMOVAL OF FLAVONOIDS STALLERGENES S.A. (FR) 2010-12-09 WO disclosed
WO-2001024808-A1 CANELO PRODUCTS AND METHODS OF MAKING AND USING SAME BIOACTIVA MICROTECHNE (US) 2001-04-12 WO disclosed