Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 14/20 | 0.36 |
| ▸ | CRHBP | P24387 | 1/20 | 0.34 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3082564 | 0.73 | ALDH1A1 (0.41) | ALDH1A1CRHBPCRHR2L3MBTL1TSHR | |
| SCHEMBL16235913 | 0.71 | PTPN1 (0.41) | ALDH1A1CRHBPCRHR2L3MBTL1TSHR | |
| SCHEMBL3081954 | 0.69 | ALDH1A1 (0.41) | ALDH1A1CRHBPCRHR2TSHRSMN1; SMN2 | |
| SCHEMBL2310858 | 0.68 | ALDH1A1 (0.41) | ALDH1A1CRHBPCRHR2L3MBTL1TSHR | |
| SCHEMBL3082671 | 0.68 | L3MBTL1 (0.49) | ALDH1A1CRHBPCRHR2L3MBTL1TSHR | |
| SCHEMBL15564118 | 0.68 | KMT2A (0.40) | ALDH1A1CRHBPCRHR2L3MBTL1TSHR | |
| SCHEMBL21128872 | 0.67 | ALDH1A1 (0.33) | ALDH1A1CRHBPCRHR2SMN1; SMN2CYP2C9 | |
| SCHEMBL21810871 | 0.67 | PTPN1 (0.50) | ALDH1A1L3MBTL1CYP2C9LMNACYP1A2 | |
| SCHEMBL20786806 | 0.67 | PTPN1 (0.46) | ALDH1A1CRHBPCRHR2L3MBTL1TSHR | |
| SCHEMBL1549875 | 0.66 | PTPN1 (0.41) | LMNAHSD17B10PTPN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010108059-A1 | SUBSTITUTED PYRIMIDINE DERIVATIVES AS ANTAGONISTS OF THE HISTAMINE H4 RECEPTOR | INCYTE CORPORATION (US) | 2010-09-23 | — | — | WO | disclosed |