Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN5 | P54829 | 1/20 | 0.38 |
| ▸ | PTPN1 | P18031 | 10/20 | 0.38 |
| ▸ | PTPRF | P10586 | 2/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | PTPRA | P18433 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | CRHBP | P24387 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.35 |
| ▸ | GSK3B | P49841 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL612016 | 0.83 | MAPK14 (0.41) | MAPT | |
| SCHEMBL21411357 | 0.78 | ALDH1A1 (0.43) | PTPN1PTPRFCA2PTPRAPOLB | |
| SCHEMBL3607693 | 0.74 | LCK (0.42) | PTPN1PTPRFCA2 | |
| SCHEMBL3715444 | 0.70 | PTPN2 (0.62) | PTPN1MEN1KMT2AL3MBTL1 | |
| SCHEMBL31648042 | 0.70 | CA2 (0.46) | PTPN5CA2MAPTL3MBTL1 | |
| SCHEMBL6192110 | 0.69 | LCK (0.38) | PTPN1CA2 | |
| SCHEMBL14343926 | 0.68 | IKBKB (0.39) | L3MBTL1 | |
| SCHEMBL20572261 | 0.68 | IKBKB (0.47) | MAPTGSK3B | |
| SCHEMBL20894252 | 0.67 | GSK3B (0.42) | PTPN1GSK3BGPR35 | |
| SCHEMBL31223032 | 0.67 | GSK3B (0.36) | POLBGSK3BGPR35 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010101302-A1 | THIENOPYRIMIDINE AS CDC7 KINASE INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-09-10 | — | — | WO | disclosed |
| CN-101316851-A | Thienopyrimidinone derivatives as melanin concentrating hormone receptor-1 antagonists | BRISTOL MYERS SQUIBB CO (US) | 2008-12-03 | — | — | CN | disclosed |