Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 10/20 | 0.51 |
| ▸ | HDAC1 | Q13547 | 8/20 | 0.51 |
| ▸ | HDAC2 | Q92769 | 8/20 | 0.51 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.51 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.51 |
| ▸ | HDAC6 | Q9UBN7 | 6/20 | 0.47 |
| ▸ | KDR | P35968 | 1/20 | 0.45 |
| ▸ | BTK | Q06187 | 2/20 | 0.42 |
| ▸ | BLK | P51451 | 1/20 | 0.42 |
| ▸ | EGFR | P00533 | 1/20 | 0.41 |
| ▸ | JAK3 | P52333 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.41 |
| ▸ | VNN1 | O95497 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3722314 | 0.88 | HDAC3 (0.51) | HDAC3HDAC1HDAC2HDAC8HDAC11 | |
| SCHEMBL2716087 | 0.75 | JAK1 (0.48) | HDAC3HDAC1HDAC2HDAC8HDAC11 | |
| SCHEMBL3723105 | 0.75 | HDAC3 (0.46) | HDAC3HDAC1HDAC2HDAC8HDAC11 | |
| SCHEMBL913709 | 0.74 | STAT6 (0.62) | EGFRJAK3 | |
| SCHEMBL3716006 | 0.73 | HDAC3 (0.46) | HDAC3HDAC1HDAC2HDAC8HDAC11 | |
| SCHEMBL913543 | 0.69 | STAT6 (0.55) | BTKEGFRJAK3MAP3K5 | |
| SCHEMBL17434737 | 0.68 | MAPT (0.44) | HDAC3HDAC1HDAC2HDAC8HDAC11 | |
| SCHEMBL17589369 | 0.68 | KMT2A (0.66) | KDRSMN1; SMN2LMNA | |
| SCHEMBL3716229 | 0.67 | CCNT1 (0.53) | HDAC3HDAC1HDAC2HDAC6BTK | |
| SCHEMBL7803055 | 0.66 | KDR (0.58) | HDAC2HDAC8HDAC6KDRSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010129802-A1 | INHIBITORS OF JAK | PORTOLA PHARMACEUTICALS, INC. (US) | 2010-11-11 | — | — | WO | disclosed |