Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 20/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3713182 | 0.88 | SYK (0.42) | SYK | |
| SCHEMBL3712339 | 0.86 | MAPK9 (0.42) | SYK | |
| SCHEMBL3714499 | 0.85 | MAPK9 (0.44) | SYK | |
| SCHEMBL3715520 | 0.83 | MAPK9 (0.43) | SYK | |
| SCHEMBL3715958 | 0.81 | MAPK9 (0.46) | SYK | |
| SCHEMBL914238 | 0.81 | STAT6 (0.56) | SYK | |
| SCHEMBL3715842 | 0.79 | JAK3 (0.51) | SYK | |
| SCHEMBL913747 | 0.79 | SYK (0.54) | SYK | |
| SCHEMBL913746 | 0.79 | SYK (0.54) | SYK | |
| SCHEMBL912277 | 0.77 | STAT6 (0.57) | SYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010129802-A1 | INHIBITORS OF JAK | PORTOLA PHARMACEUTICALS, INC. (US) | 2010-11-11 | — | — | WO | disclosed |