Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK9 | P45984 | 5/20 | 0.42 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.42 |
| ▸ | EGFR | P00533 | 1/20 | 0.41 |
| ▸ | MAPK10 | P53779 | 4/20 | 0.41 |
| ▸ | SYK | P43405 | 4/20 | 0.41 |
| ▸ | STAT6 | P42226 | 1/20 | 0.41 |
| ▸ | WEE1 | P30291 | 2/20 | 0.40 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.40 |
| ▸ | AURKA | O14965 | 3/20 | 0.40 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.40 |
| ▸ | IGF1R | P08069 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | JAK1 | P23458 | 1/20 | 0.38 |
| ▸ | JAK3 | P52333 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3714499 | 0.91 | MAPK9 (0.44) | MAPK9MAPK8EGFRMAPK10SYK | |
| SCHEMBL3715520 | 0.89 | MAPK9 (0.43) | MAPK9MAPK8EGFRMAPK10SYK | |
| SCHEMBL3713182 | 0.89 | SYK (0.42) | MAPK9MAPK8EGFRMAPK10SYK | |
| SCHEMBL3715840 | 0.86 | SYK (0.47) | SYK | |
| SCHEMBL3714738 | 0.86 | EGFR (0.53) | MAPK9MAPK8EGFRSYKAURKA | |
| SCHEMBL3715958 | 0.86 | MAPK9 (0.46) | MAPK9MAPK8EGFRMAPK10SYK | |
| SCHEMBL3721800 | 0.80 | SYK (0.46) | MAPK9MAPK8EGFRSYKAURKB | |
| SCHEMBL913880 | 0.79 | STAT6 (0.62) | SYKSTAT6JAK2JAK1JAK3 | |
| SCHEMBL3720749 | 0.77 | CCNT1 (0.51) | MAPK9MAPK8EGFRSYKALK | |
| SCHEMBL3712344 | 0.77 | JAK3 (0.59) | SYKSTAT6JAK2JAK1JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010129802-A1 | INHIBITORS OF JAK | PORTOLA PHARMACEUTICALS, INC. (US) | 2010-11-11 | — | — | WO | disclosed |