Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK9 | P45984 | 6/20 | 0.43 |
| ▸ | MAPK10 | P53779 | 5/20 | 0.43 |
| ▸ | MAPK8 | P45983 | 3/20 | 0.43 |
| ▸ | CDYL | Q9Y232 | 1/20 | 0.42 |
| ▸ | EGFR | P00533 | 5/20 | 0.41 |
| ▸ | ITK | Q08881 | 2/20 | 0.41 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.40 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.40 |
| ▸ | CDK2 | P24941 | 1/20 | 0.40 |
| ▸ | CDK9 | P50750 | 1/20 | 0.40 |
| ▸ | SYK | P43405 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | CASP3 | P42574 | 1/20 | 0.38 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.38 |
| ▸ | BTK | Q06187 | 1/20 | 0.38 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3714499 | 0.91 | MAPK9 (0.44) | MAPK9MAPK10MAPK8EGFRITK | |
| SCHEMBL3712339 | 0.89 | MAPK9 (0.42) | MAPK9MAPK10MAPK8EGFRSYK | |
| SCHEMBL3720749 | 0.88 | CCNT1 (0.51) | MAPK9MAPK8EGFRITKCCNT1 | |
| SCHEMBL3713182 | 0.85 | SYK (0.42) | MAPK9MAPK10MAPK8EGFRSYK | |
| SCHEMBL3715840 | 0.83 | SYK (0.47) | SYK | |
| SCHEMBL3715958 | 0.82 | MAPK9 (0.46) | MAPK9MAPK10MAPK8EGFRSYK | |
| SCHEMBL913417 | 0.81 | STAT6 (0.58) | MAPK9MAPK8SYK | |
| SCHEMBL3712392 | 0.80 | MAPK8 (0.45) | MAPK9MAPK8EGFRITKSYK | |
| SCHEMBL913778 | 0.79 | SYK (0.53) | MAPK9MAPK10MAPK8EGFRITK | |
| SCHEMBL913777 | 0.79 | SYK (0.53) | MAPK9MAPK10MAPK8EGFRITK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010129802-A1 | INHIBITORS OF JAK | PORTOLA PHARMACEUTICALS, INC. (US) | 2010-11-11 | — | — | WO | disclosed |