Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K4 | O95819 | 2/20 | 0.41 |
| ▸ | PGR | P06401 | 5/20 | 0.41 |
| ▸ | MAP2 | P11137 | 1/20 | 0.38 |
| ▸ | CHEK2 | O96017 | 5/20 | 0.38 |
| ▸ | MGLL | Q99685 | 2/20 | 0.37 |
| ▸ | LIPC | P11150 | 1/20 | 0.36 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.36 |
| ▸ | PIM1 | P11309 | 1/20 | 0.35 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.35 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.35 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14964175 | 0.90 | CHEK2 (0.45) | MAP4K4PGRCHEK2 | |
| SCHEMBL14655238 | 0.85 | ICMT (0.47) | PGRMAP2CHEK2 | |
| SCHEMBL3726438 | 0.83 | PARP1 (0.50) | MAP4K4PGRMAP2CHEK2 | |
| SCHEMBL3716080 | 0.80 | MAP4K4 (0.49) | MAP4K4PGRPIM1PIM2 | |
| Bromide SCHEMBL118833 | 0.79 | MAP4K4 (0.48) | MAP4K4PGRPIM1PIM2 | |
| Bromide SCHEMBL2380345 | 0.79 | MAP4K4 (0.48) | MAP4K4PGRPIM1PIM2 | |
| SCHEMBL9107283 | 0.78 | HRH4 (0.44) | MAP2CHEK2 | |
| SCHEMBL3064168 | 0.78 | KMT2A (0.46) | MAP2CHEK2 | |
| SCHEMBL30707784 | 0.78 | HRH4 (0.44) | MAP2CHEK2 | |
| SCHEMBL29414225 | 0.78 | KMT2A (0.46) | MAP2CHEK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8450354-B2 | Substituted imidazo[1,2-b]pyridazine derivatives, pharmaceutical compositions, and methods of use as β-secretase inhibitors | HIGH POINT PHARMACEUTICALS, LLC (US) | 2013-05-28 | — | — | US | claimed |
| US-8450354-B2 | Substituted imidazo[1,2-b]pyridazine derivatives, pharmaceutical compositions, and methods of use as β-secretase inhibitors | HIGH POINT PHARMACEUTICALS, LLC (US) | 2013-05-28 | — | — | US | disclosed |
| EP-2549874-A1 | SUBSTITUTED IMIDAZO[1,2-B]PYRIDAZINE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS, AND METHODS OF USE AS BETA-SECRETASE INHIBITORS | High Point Pharmaceuticals, LLC (US) | 2013-01-30 | — | — | EP | disclosed |
| WO-2010126745-A1 | SUBSTITUTED IMIDAZO[1,2-A]PYRIDINE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS, AND METHODS OF USE AS β-SECRETASE INHIBITORS | HIGH POINT PHARMACEUTICALS, LLC (US) | 2010-11-04 | — | — | WO | disclosed |