Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK2 | O96017 | 17/20 | 0.45 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | PGR | P06401 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3716079 | 0.90 | MAP4K4 (0.41) | CHEK2MAP4K4PGR | |
| SCHEMBL14964176 | 0.80 | HTR3E (0.58) | MAP4K4MEN1THRBKMT2APGR | |
| SCHEMBL7152026 | 0.78 | HTR3E (0.57) | CHEK2KMT2A | |
| SCHEMBL14655238 | 0.74 | ICMT (0.47) | CHEK2PGR | |
| SCHEMBL3726438 | 0.73 | PARP1 (0.50) | CHEK2MAP4K4MEN1KMT2APGR | |
| SCHEMBL21973456 | 0.72 | PIN1 (0.59) | CHEK2 | |
| SCHEMBL3498398 | 0.72 | CHEK2 (0.60) | CHEK2MEN1KMT2A | |
| SCHEMBL3716080 | 0.69 | MAP4K4 (0.49) | MAP4K4MEN1KMT2APGR | |
| SCHEMBL9107283 | 0.69 | HRH4 (0.44) | CHEK2 | |
| SCHEMBL17693449 | 0.69 | PIN1 (0.47) | CHEK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8450354-B2 | Substituted imidazo[1,2-b]pyridazine derivatives, pharmaceutical compositions, and methods of use as β-secretase inhibitors | HIGH POINT PHARMACEUTICALS, LLC (US) | 2013-05-28 | — | — | US | claimed |
| US-8450527-B2 | Amine derivative compounds for treating ophthalmic diseases and disorders | ACUCELA INC. (US) | 2013-05-28 | — | — | US | disclosed |