Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 8/20 | 0.77 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.77 |
| ▸ | CISD1 | Q9NZ45 | 2/20 | 0.77 |
| ▸ | THRB | P10828 | 1/20 | 0.77 |
| ▸ | ALDH1A1 | P00352 | 11/20 | 0.61 |
| ▸ | MAPT | P10636 | 7/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.61 |
| ▸ | LMNA | P02545 | 4/20 | 0.61 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.61 |
| ▸ | POLB | P06746 | 2/20 | 0.61 |
| ▸ | EGFR | P00533 | 7/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 6/20 | 0.55 |
| ▸ | HPGD | P15428 | 6/20 | 0.55 |
| ▸ | SLC16A3 | O15427 | 1/20 | 0.55 |
| ▸ | SLC16A1 | P53985 | 1/20 | 0.55 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.55 |
| ▸ | ESR1 | P03372 | 2/20 | 0.53 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.53 |
| ▸ | BLM | P54132 | 5/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3716116 | 1.00 | MEN1 (0.77) | MEN1KMT2ACISD1THRBALDH1A1 | |
| SCHEMBL1238796 | 0.87 | MEN1 (1.00) | MEN1KMT2ACISD1THRBALDH1A1 | |
| SCHEMBL19469440 | 0.82 | KMT2A (0.59) | MEN1KMT2ACISD1THRBALDH1A1 | |
| SCHEMBL5386095 | 0.82 | MAPT (0.58) | MEN1KMT2ACISD1THRBALDH1A1 | |
| SCHEMBL5386096 | 0.82 | MAPT (0.58) | MEN1KMT2ACISD1THRBALDH1A1 | |
| SCHEMBL25736025 | 0.80 | MEN1 (0.77) | MEN1KMT2ACISD1THRBALDH1A1 | |
| SCHEMBL11740232 | 0.78 | ALDH1A1 (0.80) | MEN1KMT2ACISD1THRBALDH1A1 | |
| SCHEMBL11740240 | 0.78 | ALDH1A1 (0.80) | MEN1KMT2ACISD1THRBALDH1A1 | |
| SCHEMBL5805056 | 0.78 | ALDH1A1 (0.80) | MEN1KMT2ACISD1THRBALDH1A1 | |
| SCHEMBL5805054 | 0.78 | ALDH1A1 (0.80) | MEN1KMT2ACISD1THRBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7858349-B2 | Anti-cancer compounds | THE REGENTS OF THE UNIVERSITY OF COLORADO (US) | 2010-12-28 | — | — | US | disclosed |
| WO-2010127381-A1 | DIAGNOSIS, MONITORING, PROGNOSIS, PREVENTION AND TREATMENT OF ANEURYSMS | JAMES COOK UNIVERSITY (AU) | 2010-11-11 | — | — | WO | disclosed |
| US-20090088454-A1 | ANTI-CANCER COMPOUNDS | THE REGENTS OF THE UNIVERSITY OF COLORADO (US) | 2009-04-02 | — | — | US | disclosed |
| US-7427496-B2 | Anti-cancer compounds | THE REGENTS OF THE UNIVERSITY OF COLORADO (US) | 2008-09-23 | — | — | US | disclosed |
| WO-2006093518-A2 | THIENYL COMPOUNDS FOR TREATING VIRUS-RELATED CONDITIONS | APATH, LLC (US) | 2006-09-08 | — | — | WO | disclosed |
| US-20060183772-A1 | To inhibit tumor growth in an animal; to induce apoptosis | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2006-08-17 | — | — | US | disclosed |
| US-7071168-B2 | Anti-cancer compounds and methods related thereto | THE REGENTS OF THE UNIVERSITY OF COLORADO (US) | 2006-07-04 | — | — | US | disclosed |
| US-6388054-B1 | AMINO ACID SEQUENCES OF ANTITUMOR AGENTS AND APOPTOSIS AGENTS | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2002-05-14 | — | — | US | disclosed |
| WO-2000011022-A1 | ANTI-CANCER COMPOUNDS AND METHODS RELATED THERETO | STEWART JOHN M (US) | 2000-03-02 | — | — | WO | disclosed |
| US-4410696-A | Antitumor and immunosuppressive 4-carbamoylimidazolium-5-olate derivatives | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 1983-10-18 | — | — | US | disclosed |
| EP-0075629-A1 | Imidazole derivatives, their preparation, and their pharmaceutical compositions | Sumitomo Chemical Industries Ltd. (JP) | 1983-04-06 | — | — | EP | disclosed |