Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 8/20 | 0.50 |
| ▸ | HDAC1 | Q13547 | 7/20 | 0.47 |
| ▸ | PTGES | O14684 | 3/20 | 0.45 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.41 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.40 |
| ▸ | EPAS1 | Q99814 | 2/20 | 0.40 |
| ▸ | ESR1 | P03372 | 1/20 | 0.40 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | ACACB | O00763 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3715131 | 0.89 | HDAC6 (0.46) | HDAC6HDAC1PTGESAKR1C3FFAR1 | |
| SCHEMBL3721790 | 0.87 | HDAC6 (0.41) | HDAC6HDAC1PTGESAKR1C3FFAR1 | |
| SCHEMBL13188231 | 0.86 | CSF1R (0.38) | HDAC6HDAC1PTGESAKR1C3FFAR1 | |
| SCHEMBL3714462 | 0.84 | HDAC6 (0.39) | HDAC6HDAC1PTGESAKR1C3FFAR1 | |
| Trifluoroacetic Acid SCHEMBL3719131 | 0.83 | FFAR1 (0.39) | HDAC6HDAC1PTGESAKR1C3FFAR1 | |
| SCHEMBL3719846 | 0.82 | CSF1R (0.40) | HDAC6PTGESAKR1C3FFAR1ACACB | |
| SCHEMBL3710041 | 0.81 | HDAC1 (0.46) | HDAC6HDAC1PTGESFFAR1HIF1A | |
| SCHEMBL13188474 | 0.79 | CAMK2D (0.47) | HDAC6HDAC1FFAR1HIF1AEPAS1 | |
| SCHEMBL3716099 | 0.79 | FFAR1 (0.41) | HDAC6HDAC1PTGESFFAR1HIF1A | |
| SCHEMBL3716452 | 0.78 | FFAR1 (0.40) | PTGESFFAR1HIF1AEPAS1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010100475-A1 | HYDROXAMIC ACID DERIVATIVES AS GRAM-NEGATIVE ANTIBACTERIAL AGENTS | ASTRAZENECA AB (SE) | 2010-09-10 | — | — | WO | disclosed |
| WO-2010100475-A1 | HYDROXAMIC ACID DERIVATIVES AS GRAM-NEGATIVE ANTIBACTERIAL AGENTS | ASTRAZENECA AB (SE) | 2010-09-10 | — | — | WO | disclosed |