Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 7/20 | 0.39 |
| ▸ | CTSS | P25774 | 7/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | RORC | P51449 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.34 |
| ▸ | BRS3 | P32247 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3717187 | 0.84 | HSD11B1 (0.41) | HSD11B1KMT2ARORCSMN1; SMN2 | |
| SCHEMBL3720017 | 0.84 | KMT2A (0.41) | HSD11B1CTSSKMT2ARORCSMN1; SMN2 | |
| SCHEMBL3723053 | 0.75 | KMT2A (0.48) | CTSSKMT2ASMN1; SMN2 | |
| SCHEMBL3066193 | 0.73 | HSD11B1 (0.44) | HSD11B1CTSS | |
| SCHEMBL3067380 | 0.73 | HSD11B1 (0.44) | HSD11B1CTSS | |
| SCHEMBL696098 | 0.68 | KDM4E (0.49) | CTSSSMN1; SMN2 | |
| SCHEMBL3793078 | 0.66 | CTSS (0.43) | HSD11B1CTSSKMT2A | |
| SCHEMBL3794165 | 0.66 | CTSS (0.43) | HSD11B1CTSSKMT2A | |
| SCHEMBL3072436 | 0.65 | CTSS (0.55) | CTSS | |
| SCHEMBL3067786 | 0.64 | CTSS (0.40) | HSD11B1CTSS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010121918-A1 | PROLINE DERIVATIVES AS CATHEPSIN INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2010-10-28 | — | — | WO | disclosed |