Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSL | P07711 | 2/20 | 0.43 |
| ▸ | CTSB | P07858 | 2/20 | 0.43 |
| ▸ | CTSS | P25774 | 2/20 | 0.43 |
| ▸ | CTSK | P43235 | 2/20 | 0.43 |
| ▸ | KCNJ6 | P48051 | 14/20 | 0.33 |
| ▸ | KCNJ3 | P48549 | 14/20 | 0.33 |
| ▸ | KCNJ5 | P48544 | 11/20 | 0.33 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.33 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3061642 | 1.00 | CTSL (0.43) | CTSLCTSBCTSSCTSKKCNJ6 | |
| SCHEMBL696483 | 0.86 | CTSL (0.43) | CTSLCTSBCTSSCTSKKCNJ6 | |
| SCHEMBL696484 | 0.86 | CTSL (0.43) | CTSLCTSBCTSSCTSKKCNJ6 | |
| SCHEMBL694456 | 0.84 | CTSS (0.49) | CTSLCTSBCTSSCTSK | |
| SCHEMBL696135 | 0.81 | CTSS (0.48) | CTSLCTSBCTSSCTSKKCNJ6 | |
| SCHEMBL695106 | 0.81 | CTSS (0.43) | CTSLCTSBCTSSCTSK | |
| SCHEMBL694888 | 0.81 | CTSS (0.56) | CTSLCTSBCTSSCTSKKCNJ6 | |
| SCHEMBL694908 | 0.80 | CTSS (0.57) | CTSLCTSBCTSSCTSK | |
| SCHEMBL694907 | 0.80 | CTSS (0.57) | CTSLCTSBCTSSCTSK | |
| SCHEMBL695523 | 0.80 | CTSS (0.57) | CTSLCTSBCTSSCTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010121918-A1 | PROLINE DERIVATIVES AS CATHEPSIN INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2010-10-28 | — | — | WO | disclosed |