Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 12/20 | 0.67 |
| ▸ | JAK1 | P23458 | 11/20 | 0.67 |
| ▸ | JAK3 | P52333 | 7/20 | 0.67 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.52 |
| ▸ | TYK2 | P29597 | 3/20 | 0.52 |
| ▸ | CDC7 | O00311 | 2/20 | 0.48 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.48 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.48 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.48 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.48 |
| ▸ | PAK4 | O96013 | 2/20 | 0.48 |
| ▸ | PIM1 | P11309 | 2/20 | 0.48 |
| ▸ | PRKACA | P17612 | 2/20 | 0.48 |
| ▸ | CDK2 | P24941 | 2/20 | 0.48 |
| ▸ | SYK | P43405 | 2/20 | 0.48 |
| ▸ | CSNK1A1 | P48729 | 2/20 | 0.48 |
| ▸ | CLK2 | P49760 | 2/20 | 0.48 |
| ▸ | GSK3A | P49840 | 2/20 | 0.48 |
| ▸ | GSK3B | P49841 | 2/20 | 0.48 |
| ▸ | CDK7 | P50613 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3714457 | 0.89 | JAK1 (0.58) | JAK2JAK1JAK3HDAC6TYK2 | |
| SCHEMBL3711046 | 0.83 | JAK3 (0.53) | JAK2JAK1JAK3HDAC6TYK2 | |
| SCHEMBL3716699 | 0.83 | JAK2 (0.61) | JAK2JAK1JAK3HDAC6TYK2 | |
| SCHEMBL3713922 | 0.82 | FLT4 (0.52) | JAK2JAK1JAK3HDAC6TYK2 | |
| SCHEMBL3715005 | 0.81 | PTK2 (0.46) | JAK2JAK1JAK3HDAC6TYK2 | |
| SCHEMBL3721785 | 0.81 | JAK2 (0.46) | JAK2JAK1JAK3HDAC6TYK2 | |
| SCHEMBL3714022 | 0.81 | JAK2 (0.46) | JAK2JAK1JAK3HDAC6TYK2 | |
| SCHEMBL3716516 | 0.81 | RPS6KA3 (0.47) | JAK2JAK1JAK3HDAC6TYK2 | |
| SCHEMBL15163241 | 0.81 | STAT6 (0.64) | JAK2JAK3CDK2CDK7 | |
| SCHEMBL15163225 | 0.81 | JAK2 (0.64) | JAK2JAK1JAK3HDAC6TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2403853-B1 | PYRROLOPYRIMIDINES USED AS KINASE INHIBITORS | MEDICAL RES COUNCIL TECHNOLOGY (GB) | 2013-08-14 | — | — | EP | claimed |
| WO-2010100431-A1 | PYRROLOPYRIMIDINES USED AS KINASE INHIBITORS | MEDICAL RESEARCH COUNCIL TECHNOLOGY (GB) | 2010-09-10 | — | — | WO | claimed |
| EP-2403853-B1 | PYRROLOPYRIMIDINES USED AS KINASE INHIBITORS | MEDICAL RES COUNCIL TECHNOLOGY (GB) | 2013-08-14 | — | — | EP | disclosed |
| WO-2010100431-A1 | PYRROLOPYRIMIDINES USED AS KINASE INHIBITORS | MEDICAL RESEARCH COUNCIL TECHNOLOGY (GB) | 2010-09-10 | — | — | WO | disclosed |