Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 8/20 | 0.53 |
| ▸ | HDAC6 | Q9UBN7 | 6/20 | 0.51 |
| ▸ | KDR | P35968 | 1/20 | 0.51 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.51 |
| ▸ | JAK2 | O60674 | 12/20 | 0.50 |
| ▸ | JAK1 | P23458 | 9/20 | 0.50 |
| ▸ | TYK2 | P29597 | 3/20 | 0.49 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.48 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.47 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.47 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3711049 | 0.86 | JAK3 (0.49) | JAK3HDAC6KDRAURKBJAK2 | |
| SCHEMBL3714457 | 0.85 | JAK1 (0.58) | JAK3HDAC6JAK2JAK1TYK2 | |
| SCHEMBL15163458 | 0.84 | TBK1 (0.57) | JAK3HDAC6JAK2JAK1TYK2 | |
| SCHEMBL3716698 | 0.83 | JAK2 (0.67) | JAK3HDAC6JAK2JAK1TYK2 | |
| SCHEMBL3790567 | 0.83 | STAT6 (0.65) | JAK3 | |
| SCHEMBL1284833 | 0.81 | TBK1 (0.72) | JAK3HDAC6AURKBJAK2JAK1 | |
| SCHEMBL3795183 | 0.81 | TBK1 (0.70) | JAK3KDRAURKBJAK2TYK2 | |
| SCHEMBL3717362 | 0.81 | STAT6 (0.53) | JAK3TBK1 | |
| SCHEMBL3711929 | 0.81 | JAK2 (0.53) | JAK3JAK2JAK1TYK2TBK1 | |
| SCHEMBL3711061 | 0.79 | STAT6 (0.55) | JAK3HDAC6JAK2TBK1HDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2403853-B1 | PYRROLOPYRIMIDINES USED AS KINASE INHIBITORS | MEDICAL RES COUNCIL TECHNOLOGY (GB) | 2013-08-14 | — | — | EP | claimed |
| WO-2010100431-A1 | PYRROLOPYRIMIDINES USED AS KINASE INHIBITORS | MEDICAL RESEARCH COUNCIL TECHNOLOGY (GB) | 2010-09-10 | — | — | WO | claimed |
| EP-2403853-B1 | PYRROLOPYRIMIDINES USED AS KINASE INHIBITORS | MEDICAL RES COUNCIL TECHNOLOGY (GB) | 2013-08-14 | — | — | EP | disclosed |