Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 13/20 | 0.61 |
| ▸ | JAK1 | P23458 | 11/20 | 0.61 |
| ▸ | JAK3 | P52333 | 7/20 | 0.61 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.48 |
| ▸ | TYK2 | P29597 | 6/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 6/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.44 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.44 |
| ▸ | CDK19 | Q9BWU1 | 2/20 | 0.44 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3714459 | 0.88 | EIF2AK4 (0.57) | JAK2JAK1JAK3TYK2HDAC6 | |
| SCHEMBL3716698 | 0.83 | JAK2 (0.67) | JAK2JAK1JAK3RPS6KA3TYK2 | |
| SCHEMBL3711049 | 0.82 | JAK3 (0.49) | JAK2JAK1JAK3TYK2HDAC6 | |
| SCHEMBL15163225 | 0.81 | JAK2 (0.64) | JAK2JAK1JAK3TYK2HDAC6 | |
| SCHEMBL3713927 | 0.81 | TBK1 (0.48) | JAK2JAK1JAK3RPS6KA3TYK2 | |
| SCHEMBL13733806 | 0.81 | JAK2 (0.63) | JAK2JAK1JAK3RPS6KA3TYK2 | |
| SCHEMBL3721787 | 0.80 | RPS6KA3 (0.48) | JAK2JAK1JAK3RPS6KA3TYK2 | |
| SCHEMBL3714024 | 0.80 | RPS6KA3 (0.48) | JAK2JAK1JAK3RPS6KA3TYK2 | |
| SCHEMBL13735183 | 0.80 | JAK2 (0.57) | JAK2JAK1JAK3RPS6KA3TYK2 | |
| SCHEMBL3715010 | 0.80 | PTK2 (0.48) | JAK2JAK1JAK3RPS6KA3TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2403853-B1 | PYRROLOPYRIMIDINES USED AS KINASE INHIBITORS | MEDICAL RES COUNCIL TECHNOLOGY (GB) | 2013-08-14 | — | — | EP | claimed |
| WO-2010100431-A1 | PYRROLOPYRIMIDINES USED AS KINASE INHIBITORS | MEDICAL RESEARCH COUNCIL TECHNOLOGY (GB) | 2010-09-10 | — | — | WO | claimed |
| EP-2403853-B1 | PYRROLOPYRIMIDINES USED AS KINASE INHIBITORS | MEDICAL RES COUNCIL TECHNOLOGY (GB) | 2013-08-14 | — | — | EP | disclosed |
| WO-2010100431-A1 | PYRROLOPYRIMIDINES USED AS KINASE INHIBITORS | MEDICAL RESEARCH COUNCIL TECHNOLOGY (GB) | 2010-09-10 | — | — | WO | disclosed |