Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.60 |
| ▸ | AOC2 | O75106 | 5/20 | 0.42 |
| ▸ | MAOA | P21397 | 5/20 | 0.42 |
| ▸ | MAOB | P27338 | 5/20 | 0.42 |
| ▸ | DAO | P14920 | 1/20 | 0.42 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
| ▸ | HTR1D | P28221 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 2/20 | 0.37 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.36 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.36 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.36 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8429124 | 0.83 | CA2 (0.51) | HRH3HTR1AHTR1DCA2 | |
| SCHEMBL8426754 | 0.83 | CA2 (0.51) | HRH3HTR1AHTR1DCA2 | |
| SCHEMBL1682899 | 0.83 | CA2 (0.51) | HRH3HTR1AHTR1DCA2 | |
| SCHEMBL452349 | 0.82 | HRH3 (0.49) | HRH3AOC2MAOAMAOBDAO | |
| SCHEMBL6723015 | 0.79 | HRH3 (0.53) | HRH3AOC2MAOAMAOBDAO | |
| SCHEMBL10622758 | 0.79 | HRH3 (0.47) | HRH3AOC2MAOAMAOBDAO | |
| SCHEMBL10622772 | 0.79 | HRH3 (0.47) | HRH3AOC2MAOAMAOBDAO | |
| SCHEMBL28390611 | 0.78 | HRH3 (0.46) | HRH3AOC2MAOAMAOBDAO | |
| SCHEMBL16684498 | 0.78 | SMN1; SMN2 (0.47) | HRH3MAOAMAOBTSHR | |
| SCHEMBL9843265 | 0.77 | HRH3 (0.45) | HRH3AOC2MAOAMAOBDAO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2234995-A1 | LEUKOTRIENE B4 INHIBITORS | F. Hoffmann-La Roche AG (CH) | 2010-10-06 | — | — | EP | claimed |
| WO-2009077385-A1 | LEUKOTRIENE B4 INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2009-06-25 | — | — | WO | claimed |
| JP-8092246-A | — | — | None | — | — | JP | disclosed |
| EP-2234995-A1 | LEUKOTRIENE B4 INHIBITORS | F. Hoffmann-La Roche AG (CH) | 2010-10-06 | — | — | EP | disclosed |
| WO-2009077385-A1 | LEUKOTRIENE B4 INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2009-06-25 | — | — | WO | disclosed |
| JP-H0892246-A | DIHYDROBENZOFURAN DERIVATIVE AND LIQUID CRYSTAL COMPOSITION CONTAINING THE SAME | DAINIPPON INK & CHEM INC | 1996-04-09 | — | — | JP | disclosed |
| US-5175173-A | Reduced side effects | SUN JUNG HUI (US) | 1992-12-29 | — | — | US | disclosed |
| US-5126364-A | Antiemetics, antipsychotics | ERBAMONT, INC. (US) | 1992-06-30 | — | — | US | disclosed |
| EP-0234872-B1 | CARBOXAMIDES USEFUL AS ANTIEMETIC OR ANTIPSYCHOTIC AGENTS | Erbamont Inc. (US) | 1991-11-27 | — | — | EP | disclosed |
| EP-0147044-B1 | BENZOFURANCARBOXAMIDES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL PREPARATIONS CONTAINING THEM | ADRIA LABORATORIES INC. (US) | 1990-04-25 | — | — | EP | disclosed |
| US-4888353-A | Carboxamides useful as antiemetic or antipsychotic agents | ERBAMONT, INC. (US) | 1989-12-19 | — | — | US | disclosed |
| EP-0234872-A1 | Carboxamides useful as antiemetic or antipsychotic agents | Erbamont Inc. (US) | 1987-09-02 | — | — | EP | disclosed |
| EP-0147044-A2 | Benzofurancarboxamides, process for their preparation and pharmaceutical preparations containing them | ADRIA LABORATORIES INC. (US) | 1985-07-03 | — | — | EP | disclosed |
| US-4254140-A | USED FOR CARDIOVASCULAR DISORDERS; HYPOTENSIVE AGENT | SMITHKLINE CORPORATION (US) | 1981-03-03 | — | — | US | disclosed |