Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.45 |
| ▸ | GSTP1 | P09211 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | AOC2 | O75106 | 5/20 | 0.38 |
| ▸ | MAOA | P21397 | 5/20 | 0.38 |
| ▸ | MAOB | P27338 | 5/20 | 0.38 |
| ▸ | DAO | P14920 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.36 |
| ▸ | HTR1A | P08908 | 2/20 | 0.36 |
| ▸ | HTR1D | P28221 | 1/20 | 0.36 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.35 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.35 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | IDO1 | P14902 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9843260 | 1.00 | HRH3 (0.45) | HRH3GSTP1ALDH1A1MAPTAOC2 | |
| SCHEMBL9197193 | 0.85 | HTR1A (0.48) | ALDH1A1MAPTSIGMAR1HTR1AHTR1D | |
| SCHEMBL10622758 | 0.81 | HRH3 (0.47) | HRH3AOC2MAOAMAOBDAO | |
| SCHEMBL10622772 | 0.81 | HRH3 (0.47) | HRH3AOC2MAOAMAOBDAO | |
| SCHEMBL3717543 | 0.77 | HRH3 (0.60) | HRH3AOC2MAOAMAOBDAO | |
| SCHEMBL452349 | 0.77 | HRH3 (0.49) | HRH3AOC2MAOAMAOBDAO | |
| SCHEMBL436302 | 0.74 | ALDH1A1 (0.46) | GSTP1ALDH1A1MAPTPOLBHPGD | |
| SCHEMBL28390611 | 0.73 | HRH3 (0.46) | HRH3AOC2MAOAMAOBDAO | |
| SCHEMBL10366357 | 0.71 | HTR1A (0.50) | HRH3AOC2MAOAMAOBDAO | |
| SCHEMBL6723015 | 0.71 | HRH3 (0.53) | HRH3AOC2MAOAMAOBDAO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240150269-A1 | PROCESSES FOR THE PREPARATION OF ORTHO-ALLYLATED HYDROXY ARYL COMPOUNDS | MCMASTER UNIVERSITY (CA) | 2024-05-09 | — | — | US | disclosed |
| US-11795127-B2 | Processes for the preparation of ortho-allylated hydroxy aryl compounds | MCMASTER UNIVERSITY (CA) | 2023-10-24 | — | — | US | disclosed |
| US-20230113567-A1 | PROCESSES FOR THE PREPARATION OF ORTHO-ALLYLATED HYDROXY ARYL COMPOUNDS | MCMASTER UNIVERSITY (CA) | 2023-04-13 | — | — | US | disclosed |
| EP-4157811-A1 | PROCESSES FOR THE PREPARATION OF ORTHO-ALLYLATED HYDROXY ARYL COMPOUNDS | McMaster University (CA) | 2023-04-05 | — | — | EP | disclosed |
| US-20210380513-A1 | PROCESSES FOR THE PREPARATION OF ORTHO-ALLYLATED HYDROXY ARYL COMPOUNDS | MCMASTER UNIVERSITY (CA) | 2021-12-09 | — | — | US | disclosed |
| WO-2021237371-A1 | PROCESSES FOR THE PREPARATION OF ORTHO-ALLYLATED HYDROXY ARYL COMPOUNDS | MCMASTER UNIVERSITY (CA) | 2021-12-02 | — | — | WO | disclosed |
| CN-101671304-A | Ionic liquid containing cinnamyl functional groups and preparation method thereof | UNIV TIANJIN POLYTECHNIC | 2010-03-17 | — | — | CN | disclosed |
| EP-0420570-A2 | Trans 2,3-disubstituted-2,3-dihydro-5-hydroxy-benzofurans as inhibitors of leukotriene biosynthesis | MERCK & CO. INC. (US) | 1991-04-03 | — | — | EP | disclosed |
| US-4975457-A | Antiinflammatory agent; enzyme inhibitor | MERCK & CO., INC. (US) | 1990-12-04 | — | — | US | disclosed |
| US-4966907-A | ANTIINFLAMMATORY AGENT, ANTIALLERGENS | MERCK & CO., INC. (US) | 1990-10-30 | — | — | US | disclosed |
| US-4686235-A | TOPICAL | MERCK & CO., INC. (US) | 1987-08-11 | — | — | US | disclosed |
| US-4686235-A | TOPICAL | MERCK & CO., INC. (US) | 1987-08-11 | — | — | US | disclosed |
| US-4686235-A | TOPICAL | MERCK & CO., INC. (US) | 1987-08-11 | — | — | US | disclosed |
| EP-0199235-A2 | Phenylalkyl-2,3-dihydrobenzofurans and analogs useful as anti-inflammatory agents | MERCK & CO. INC. (US) | 1986-10-29 | — | — | EP | disclosed |
| EP-0199235-A2 | Phenylalkyl-2,3-dihydrobenzofurans and analogs useful as anti-inflammatory agents | MERCK & CO. INC. (US) | 1986-10-29 | — | — | EP | disclosed |
| US-4537903-A | Substituted cinnamyl-2,3-dihydrobenzofuran and analogs useful as anti-inflammatory agents | MERCK & CO., INC. (US) | 1985-08-27 | — | — | US | disclosed |
| US-4537903-A | Substituted cinnamyl-2,3-dihydrobenzofuran and analogs useful as anti-inflammatory agents | MERCK & CO., INC. (US) | 1985-08-27 | — | — | US | disclosed |
| US-4537903-A | Substituted cinnamyl-2,3-dihydrobenzofuran and analogs useful as anti-inflammatory agents | MERCK & CO., INC. (US) | 1985-08-27 | — | — | US | disclosed |
| EP-0143952-A1 | Substituted cinnamyl-2,3-dihydrobenzopyrans and cinnamylphenols useful as anti-inflammatory agents | MERCK & CO. INC. (US) | 1985-06-12 | — | — | EP | disclosed |
| EP-0143952-A1 | Substituted cinnamyl-2,3-dihydrobenzopyrans and cinnamylphenols useful as anti-inflammatory agents | MERCK & CO. INC. (US) | 1985-06-12 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230113567-A1 | PROCESSES FOR THE PREPARATION OF ORTHO-ALLYLATED HYDROXY ARYL COMPOUNDS | ADH1A, ADH1C, AHR | HRH3 53/4885GSTP1 1490/4885ALDH1A1 52/4885 |
| US-20210380513-A1 | PROCESSES FOR THE PREPARATION OF ORTHO-ALLYLATED HYDROXY ARYL COMPOUNDS | ADH1A, ADH1C, AHR | HRH3 53/4885GSTP1 1490/4885ALDH1A1 52/4885 |
| US-11795127-B2 | Processes for the preparation of ortho-allylated hydroxy aryl compounds | ADH1A, ADH1C, AHR | HRH3 53/4885GSTP1 1490/4885ALDH1A1 52/4885 |
| US-20240150269-A1 | PROCESSES FOR THE PREPARATION OF ORTHO-ALLYLATED HYDROXY ARYL COMPOUNDS | ADH1A, ADH1C, AHR | HRH3 72/4885GSTP1 1409/4885ALDH1A1 28/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.