Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IRAK1 | P51617 | 2/20 | 0.44 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.44 |
| ▸ | JAK2 | O60674 | 2/20 | 0.43 |
| ▸ | JAK3 | P52333 | 2/20 | 0.43 |
| ▸ | JAK1 | P23458 | 1/20 | 0.43 |
| ▸ | TYK2 | P29597 | 1/20 | 0.43 |
| ▸ | ACVR1B | P36896 | 1/20 | 0.42 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.42 |
| ▸ | PFKFB3 | Q16875 | 5/20 | 0.42 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | PIM1 | P11309 | 1/20 | 0.41 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.41 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.41 |
| ▸ | JUN | P05412 | 1/20 | 0.39 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.39 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.39 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.39 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.38 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3721843 | 0.88 | ACVR1B (0.44) | JAK2JAK3JAK1TYK2ACVR1B | |
| SCHEMBL3716550 | 0.88 | ACVR1B (0.42) | IRAK1IRAK4JAK2JAK3JAK1 | |
| SCHEMBL3722828 | 0.81 | ACVR1B (0.46) | ACVR1BTGFBR1CHEK1PIM1PIM3 | |
| SCHEMBL3659080 | 0.81 | CYP1A2 (0.45) | CYP1A2MAPK10TRPM8FFAR1MITF | |
| SCHEMBL3724847 | 0.80 | ACVR1B (0.44) | IRAK1ACVR1BTGFBR1PIM1PIM3 | |
| SCHEMBL3722316 | 0.78 | ACVR1B (0.43) | IRAK1IRAK4ACVR1BTGFBR1PIM1 | |
| SCHEMBL3721740 | 0.77 | TGFBR1 (0.42) | TGFBR1FFAR1 | |
| SCHEMBL3718360 | 0.76 | TGFBR1 (0.41) | TGFBR1CHEK1CYP1A2 | |
| SCHEMBL3658377 | 0.76 | ABL1 (0.45) | TGFBR1PIM1 | |
| SCHEMBL4172633 | 0.76 | IRAK1 (0.48) | IRAK1IRAK4JAK2JAK3ACVR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2242742-B1 | PYRIDINE DERIVATIVES | NOVARTIS AG (CH) | 2015-12-02 | — | — | EP | disclosed |
| EP-2242742-A2 | ORGANIC COMPOUNDS | Novartis AG (CH) | 2010-10-27 | — | — | EP | disclosed |
| WO-2009087212-A2 | PYRIDINE DERIVATIVES | NOVARTIS AG (CH) | 2009-07-16 | — | — | WO | disclosed |