Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IRAK1 | P51617 | 3/20 | 0.48 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.48 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.42 |
| ▸ | ACVR1B | P36896 | 1/20 | 0.41 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.41 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | TRPM8 | Q7Z2W7 | 2/20 | 0.40 |
| ▸ | MITF | O75030 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | PIM1 | P11309 | 1/20 | 0.39 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.39 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.39 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.39 |
| ▸ | JUN | P05412 | 1/20 | 0.38 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.38 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3717702 | 0.76 | IRAK1 (0.44) | IRAK1IRAK4ACVR1BTGFBR1MAPT | |
| SCHEMBL4177437 | 0.74 | PIM1 (0.50) | IRAK1IRAK4PIM1CYP2C19FLT3 | |
| SCHEMBL22874228 | 0.68 | CYP2A6 (0.68) | CYP2A6LMNASMN1; SMN2L3MBTL1PIM1 | |
| SCHEMBL29561753 | 0.68 | PIM1 (0.60) | ACVR1BTGFBR1CYP2A6MAPTLMNA | |
| SCHEMBL357658 | 0.68 | PIM1 (0.60) | ACVR1BTGFBR1CYP2A6MAPTLMNA | |
| SCHEMBL3721843 | 0.68 | ACVR1B (0.44) | DYRK1AACVR1BTGFBR1MAPTPIM1 | |
| SCHEMBL3716550 | 0.67 | ACVR1B (0.42) | IRAK1IRAK4DYRK1AACVR1BTGFBR1 | |
| SCHEMBL3722828 | 0.67 | ACVR1B (0.46) | DYRK1AACVR1BTGFBR1PIM1PIM3 | |
| SCHEMBL29736927 | 0.67 | DYRK1A (0.69) | DYRK1ACYP2A6MAPTLMNASMN1; SMN2 | |
| SCHEMBL12535875 | 0.67 | DYRK1A (0.69) | DYRK1ACYP2A6MAPTLMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8343966-B2 | Organic compounds | NOVARTIS AG (CH) | 2013-01-01 | — | — | US | disclosed |
| US-20090215776-A1 | Organic compounds | ADCOCK CLAIRE | 2009-08-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090215776-A1 | Organic compounds | REN, RXFP1, MYLK | IRAK1 356/4885IRAK4 569/4885DYRK1A 4748/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.