SCHEMBL3717829

SCHEMBL3717829

OC(c1c(F)cccc1F)C1CC1

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PDE2A O00408 1/20 0.43
CES2 O00748 2/20 0.42
CES1 P23141 2/20 0.42
EPHX1 P07099 1/20 0.34
IDO1 P14902 6/20 0.33
TDO2 P48775 2/20 0.33
CYP3A4 P08684 3/20 0.32
CYP2D6 P10635 2/20 0.32
CYP2B6 P20813 2/20 0.32
KCNH2 Q12809 2/20 0.32
CYP1A2 P05177 1/20 0.32
HTR2A P28223 2/20 0.32
HTR2C P28335 1/20 0.32
HTR7 P34969 1/20 0.32
IDH1 O75874 1/20 0.32
DRD2 P14416 1/20 0.32
DRD3 P35462 1/20 0.32
KDM4E B2RXH2 1/20 0.32
GAA P10253 1/20 0.32
SLC6A2 P23975 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16861612 0.87 P2RX7 (0.38) PDE2ACES2CES1IDO1TDO2
SCHEMBL31582720 0.87 PDE2A (0.38) PDE2ACES2CES1EPHX1KDM4E
SCHEMBL19865282 0.78 PDE2A (0.40) PDE2AHTR2AHTR2CHTR7
SCHEMBL2423911 0.78 PDE2A (0.40) PDE2AIDO1TDO2CYP2D6HTR2A
SCHEMBL5485147 0.77 PDE2A (0.54) PDE2ACES2CES1IDO1TDO2
SCHEMBL29591877 0.77 PDE2A (0.54) PDE2ACES2CES1IDO1TDO2
SCHEMBL1350025 0.75 PDE2A (0.41) PDE2AIDO1TDO2SLC6A2SLC6A4
SCHEMBL18249627 0.75 CES2 (0.41) CES2CES1EPHX1CYP1A2KDM4E
SCHEMBL31521474 0.75 PDE2A (0.45) PDE2ACES2CES1CYP3A4KCNH2
SCHEMBL3160302 0.74 EPHX1 (0.37) CES2CES1EPHX1IDO1CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2010131146-A1 CYCLOBUTENEDIONE DERIVATIVES PFIZER LIMITED (GB) 2010-11-18 WO disclosed
WO-2010131146-A1 CYCLOBUTENEDIONE DERIVATIVES PFIZER LIMITED (GB) 2010-11-18 WO disclosed
WO-2010131147-A1 CYCLOBUTENEDIONE DERIVATIVES PFIZER LIMITED (GB) 2010-11-18 WO disclosed
WO-2010131147-A1 CYCLOBUTENEDIONE DERIVATIVES PFIZER LIMITED (GB) 2010-11-18 WO disclosed
WO-2010131145-A1 CYCLOBUTENEDIONE DERIVATIVES PFIZER LIMITED (GB) 2010-11-18 WO disclosed
WO-2010131145-A1 CYCLOBUTENEDIONE DERIVATIVES PFIZER LIMITED (GB) 2010-11-18 WO disclosed