Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 8/20 | 0.57 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.57 |
| ▸ | CDC42BPA | Q5VT25 | 1/20 | 0.51 |
| ▸ | MELK | Q14680 | 1/20 | 0.49 |
| ▸ | PARP1 | P09874 | 2/20 | 0.46 |
| ▸ | DHODH | Q02127 | 1/20 | 0.46 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.46 |
| ▸ | MKNK1 | Q9BUB5 | 3/20 | 0.46 |
| ▸ | MKNK2 | Q9HBH9 | 3/20 | 0.46 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.45 |
| ▸ | HTR3A | P46098 | 1/20 | 0.42 |
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
| ▸ | DRD1 | P21728 | 1/20 | 0.41 |
| ▸ | DRD3 | P35462 | 1/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3718200 | 0.83 | ROCK2 (0.61) | ROCK2ROCK1CDC42BPAHTR3A | |
| SCHEMBL3807004 | 0.82 | ROCK2 (0.43) | ROCK2ROCK1CDC42BPAMELKPARP1 | |
| SCHEMBL3801724 | 0.79 | HTT (0.54) | ROCK2ROCK1MELKMKNK1MKNK2 | |
| SCHEMBL3713988 | 0.79 | ROCK2 (0.69) | ROCK2ROCK1CDC42BPAMELK | |
| SCHEMBL20290838 | 0.77 | MELK (0.70) | ROCK2ROCK1CDC42BPAMELKMKNK2 | |
| SCHEMBL3243986 | 0.76 | ROCK2 (0.66) | ROCK2ROCK1CDC42BPAMELK | |
| SCHEMBL3714539 | 0.75 | MELK (0.56) | ROCK2ROCK1MELKMKNK1MKNK2 | |
| SCHEMBL3722812 | 0.75 | MELK (0.55) | ROCK2ROCK1MELKPARP1MKNK1 | |
| SCHEMBL3656437 | 0.75 | MKNK2 (0.61) | ROCK2ROCK1MELKMKNK1MKNK2 | |
| SCHEMBL13885328 | 0.75 | PSMB1 (0.54) | CHEK1CHEK2DRD2DRD1DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2234618-A1 | BENZOPYRANS AND ANALOGS AS RHO KINASE INHIBITORS | The Scripps Research Institute (US) | 2010-10-06 | — | — | EP | disclosed |
| WO-2009079008-A1 | BENZOPYRANS AND ANALOGS AS RHO KINASE INHIBITORS | FENG YANGBO (US) | 2009-06-25 | — | — | WO | disclosed |