Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | RAF1 | P04049 | 3/20 | 0.34 |
| ▸ | BDKRB1 | P46663 | 1/20 | 0.33 |
| ▸ | GPBAR1 | Q8TDU6 | 2/20 | 0.33 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | MITF | O75030 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | FAAH | O00519 | 1/20 | 0.32 |
| ▸ | PROKR1 | Q8TCW9 | 1/20 | 0.32 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.32 |
| ▸ | SSTR5 | P35346 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3728515 | 0.92 | EPHX2 (0.35) | GAAMAPTRAF1BDKRB1EPHX2 | |
| SCHEMBL3722520 | 0.92 | BDKRB1 (0.41) | GAAMAPTMAPK1RAF1BDKRB1 | |
| SCHEMBL3722273 | 0.92 | PPARG (0.35) | GAARAF1BDKRB1EPHX2 | |
| SCHEMBL3729297 | 0.85 | KMT2A (0.35) | GAAMAPTMAPK1EPHX2KDM4E | |
| SCHEMBL3795493 | 0.85 | GAA (0.34) | GAAGPBAR1FAAHPROKR1 | |
| SCHEMBL13191233 | 0.84 | BDKRB1 (0.44) | BDKRB1EPHX2 | |
| SCHEMBL3722724 | 0.84 | MEN1 (0.36) | GAARAF1BDKRB1GPBAR1EPHX2 | |
| SCHEMBL3718253 | 0.83 | GAA (0.33) | GAAMAPTEPHX2KDM4EPROKR1 | |
| SCHEMBL3719005 | 0.83 | MAPK10 (0.35) | GAAMAPTKDM4E | |
| SCHEMBL3801380 | 0.82 | CNR1 (0.42) | BDKRB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010097373-A1 | COMPOUNDS FOR USE AS BRADYKININ B1 ANTAGONISTS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-09-02 | — | — | WO | disclosed |