Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | PROKR1 | Q8TCW9 | 1/20 | 0.32 |
| ▸ | BRAF | P15056 | 3/20 | 0.32 |
| ▸ | LIMK1 | P53667 | 2/20 | 0.32 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.32 |
| ▸ | LIMK2 | P53671 | 1/20 | 0.32 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.31 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.31 |
| ▸ | ESRRA | P11474 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | HTR2A | P28223 | 1/20 | 0.30 |
| ▸ | HTR2C | P28335 | 1/20 | 0.30 |
| ▸ | HTR2B | P41595 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3719005 | 0.87 | MAPK10 (0.35) | GAAMEN1KMT2ANPSR1MAPK10 | |
| SCHEMBL3729297 | 0.86 | KMT2A (0.35) | GAAPROKR1EPHX2KMT2AMAPK10 | |
| SCHEMBL3722529 | 0.86 | GAA (0.34) | GAAEPHX2MEN1KMT2ANPSR1 | |
| SCHEMBL3718251 | 0.84 | P2RX7 (0.39) | P2RX7EPHX2MEN1KMT2ANPSR1 | |
| SCHEMBL3728515 | 0.83 | EPHX2 (0.35) | GAAPROKR1EPHX2MAPK10KDM4E | |
| SCHEMBL3722520 | 0.83 | BDKRB1 (0.41) | GAABRAFEPHX2KDM4EMAPT | |
| SCHEMBL3718255 | 0.83 | GAA (0.34) | GAAPROKR1EPHX2KDM4EMAPT | |
| SCHEMBL3722273 | 0.83 | PPARG (0.35) | GAAEPHX2MEN1KMT2AMAPK10 | |
| SCHEMBL3722724 | 0.83 | MEN1 (0.36) | GAAEPHX2MEN1KMT2AMAPK10 | |
| SCHEMBL3795493 | 0.82 | GAA (0.34) | GAAPROKR1LIMK1P2RX7LIMK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010097373-A1 | COMPOUNDS FOR USE AS BRADYKININ B1 ANTAGONISTS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-09-02 | — | — | WO | disclosed |