Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MAP4K1 | Q92918 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | NR1I2 | O75469 | 2/20 | 0.37 |
| ▸ | SMARCA2 | P51531 | 2/20 | 0.37 |
| ▸ | SMARCA4 | P51532 | 2/20 | 0.37 |
| ▸ | PBRM1 | Q86U86 | 2/20 | 0.37 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.37 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.37 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.37 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.37 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.37 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1318813 | 0.96 | MAPT (0.48) | MAPTCYP1A2CYP2D6LMNAKMT2A | |
| SCHEMBL3717623 | 0.82 | PDPK1 (0.52) | MAPTCYP1A2CYP2D6LMNAKMT2A | |
| SCHEMBL605180 | 0.81 | HRH4 (0.63) | HRH4 | |
| SCHEMBL1319437 | 0.80 | CYP1A2 (0.56) | MAPTCYP1A2CYP2D6LMNAKMT2A | |
| SCHEMBL3720514 | 0.79 | MAPT (0.50) | MAPTCYP1A2CYP2D6LMNAKMT2A | |
| SCHEMBL83400 | 0.78 | CUL4A (0.38) | MAPTLMNAKMT2AMAP4K1KDM4E | |
| SCHEMBL1320233 | 0.77 | MAP4K1 (0.38) | MAPTLMNAMAP4K1KDM4EHPGD | |
| SCHEMBL3205548 | 0.77 | MAPT (0.51) | MAPTCYP1A2CYP2D6LMNAKMT2A | |
| SCHEMBL5190994 | 0.76 | NOS2 (0.56) | — | |
| SCHEMBL1319079 | 0.74 | MAPT (0.51) | MAPTCYP1A2CYP2D6LMNAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010120854-A1 | CHEMICAL COMPOUNDS | GLAXOSMITHKLINE LLC (US) | 2010-10-21 | — | — | WO | disclosed |
| WO-2010120854-A1 | CHEMICAL COMPOUNDS | GLAXOSMITHKLINE LLC (US) | 2010-10-21 | — | — | WO | disclosed |