Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 8/20 | 0.40 |
| ▸ | RAB9A | P51151 | 8/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.40 |
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.40 |
| ▸ | RELA | Q04206 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | F2RL3 | Q96RI0 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.36 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.36 |
| ▸ | ABL1 | P00519 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3791987 | 0.83 | KEAP1 (0.44) | KEAP1NPC1RAB9ASMN1; SMN2MAPT | |
| SCHEMBL27009238 | 0.81 | SCN4A (0.51) | KEAP1NPC1RAB9ASMN1; SMN2MAPT | |
| SCHEMBL13045974 | 0.81 | KMT2A (0.59) | KEAP1NPC1RAB9ASMN1; SMN2MAPT | |
| SCHEMBL26251788 | 0.80 | NPC1 (0.43) | NPC1RAB9AMAPTGAAF2RL3 | |
| SCHEMBL2615403 | 0.76 | KEAP1 (0.64) | KEAP1NPC1RAB9ASMN1; SMN2MAPT | |
| SCHEMBL26251804 | 0.75 | KCNH2 (0.38) | KEAP1NPC1RAB9AKMT2AMEN1 | |
| SCHEMBL4313599 | 0.75 | SCN4A (0.48) | NPC1RAB9ASMN1; SMN2MAPTALDH1A1 | |
| SCHEMBL28088809 | 0.71 | RAB9A (0.43) | KEAP1NPC1RAB9ASMN1; SMN2MAPT | |
| SCHEMBL3447669 | 0.70 | KMT2A (0.48) | KEAP1NPC1RAB9ASMN1; SMN2MAPT | |
| SCHEMBL13273051 | 0.70 | DYRK1A (0.44) | KEAP1NPC1RAB9ASMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2217239-A2 | MODULATION OF PROTEIN TRAFFICKING | Foldrx Pharmaceuticals, Inc. (US) | 2010-08-18 | — | — | EP | disclosed |
| WO-2009062118-A2 | MODULATION OF PROTEIN TRAFFICKING | FOLDRX PHARMACEUTICALS, INC. (US) | 2009-05-14 | — | — | WO | disclosed |