Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 12/20 | 0.56 |
| ▸ | CYP11B2 | P19099 | 3/20 | 0.52 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.49 |
| ▸ | MAOB | P27338 | 1/20 | 0.44 |
| ▸ | AGXT | P21549 | 1/20 | 0.44 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.44 |
| ▸ | SYK | P43405 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18015900 | 0.84 | KIF11 (0.55) | KIF11CYP11B2CYP11B1 | |
| SCHEMBL3717047 | 0.83 | TAAR1 (0.47) | TAAR1MAOBAGXTSYK | |
| SCHEMBL18014710 | 0.81 | KIF11 (0.53) | KIF11CYP11B2CYP11B1 | |
| SCHEMBL30139652 | 0.81 | KIF11 (0.53) | KIF11TAAR1MAOB | |
| SCHEMBL297408 | 0.81 | KIF11 (0.53) | KIF11TAAR1MAOB | |
| SCHEMBL21116015 | 0.80 | KIF11 (0.51) | KIF11CYP11B2CYP11B1 | |
| SCHEMBL21116892 | 0.78 | KIF11 (0.76) | KIF11CYP11B2CYP11B1 | |
| SCHEMBL894079 | 0.78 | AGXT (0.69) | KIF11TAAR1MAOBAGXTSYK | |
| SCHEMBL3727318 | 0.77 | TAAR1 (0.45) | TAAR1MAOBAGXTSYK | |
| SCHEMBL6120541 | 0.77 | KIF11 (0.69) | KIF11CYP11B2CYP11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8614201-B2 | Heterocyclic amides as modulators of TRPA1 | JANSSEN PHARMACEUTICA NV (BE) | 2013-12-24 | — | — | US | claimed |
| WO-2010141805-A1 | HETEROCYCLIC AMIDES AS MODULATORS OF TRPA1 | JANSSEN PHARMACEUTICA NV (BE) | 2010-12-09 | — | — | WO | claimed |
| US-8614201-B2 | Heterocyclic amides as modulators of TRPA1 | JANSSEN PHARMACEUTICA NV (BE) | 2013-12-24 | — | — | US | disclosed |
| WO-2010141805-A1 | HETEROCYCLIC AMIDES AS MODULATORS OF TRPA1 | JANSSEN PHARMACEUTICA NV (BE) | 2010-12-09 | — | — | WO | disclosed |