Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 13/20 | 0.51 |
| ▸ | CYP11B2 | P19099 | 5/20 | 0.49 |
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
| ▸ | HTR2C | P28335 | 1/20 | 0.42 |
| ▸ | HTR2B | P41595 | 1/20 | 0.42 |
| ▸ | CYP11B1 | P15538 | 3/20 | 0.42 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18015900 | 0.83 | KIF11 (0.55) | KIF11CYP11B2CYP11B1 | |
| SCHEMBL6600224 | 0.82 | KIF11 (0.49) | KIF11HTR2AHTR2CHTR2BFFAR1 | |
| SCHEMBL18014710 | 0.81 | KIF11 (0.53) | KIF11CYP11B2CYP11B1FFAR1 | |
| SCHEMBL13118159 | 0.80 | AGXT (0.59) | KIF11HTR2AHTR2CHTR2BFFAR1 | |
| SCHEMBL3718586 | 0.80 | KIF11 (0.56) | KIF11CYP11B2CYP11B1 | |
| SCHEMBL28161128 | 0.79 | CTSS (0.48) | HTR2AHTR2CHTR2B | |
| SCHEMBL21115995 | 0.78 | HTR2A (0.63) | HTR2AHTR2CHTR2B | |
| SCHEMBL13533000 | 0.78 | AGXT (0.56) | — | |
| SCHEMBL24721248 | 0.77 | KIF11 (0.56) | KIF11CYP11B2CYP11B1FFAR1 | |
| SCHEMBL21116472 | 0.76 | TAAR1 (0.50) | CYP11B2CYP11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3052495-B1 | NOVEL BICYCLIC PYRIDINONES AS GAMMA-SECRETASE MODULATORS | PFIZER (US) | 2019-06-26 | — | — | EP | disclosed |