SCHEMBL3718636

SCHEMBL3718636

CC(C#N)C(=O)OC(C#N)C#N

nearest known ligand 0.30

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
TSHR P16473 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7775457 0.83 TSHR (0.42) TSHR
SCHEMBL11566231 0.79 DPP4 (0.33)
SCHEMBL7645726 0.75
SCHEMBL9347901 0.73
SCHEMBL18643740 0.73
SCHEMBL28446509 0.73
SCHEMBL16061080 0.72
SCHEMBL18982823 0.71
SCHEMBL163958 0.71
SCHEMBL30193793 0.71

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250043290-A1 RNA SEQUENCES THAT INDUCE FLUORESCENCE OF SMALL MOLECULE FLUOROPHORES, MOLECULAR COMPLEXES, SENSORS, AND METHODS OF USE THEREOF CORNELL UNIVERSITY 2025-02-06 US disclosed
WO-2023097013-A1 RNA SEQUENCES THAT INDUCE FLUORESCENCE OF SMALL MOLECULE FLUOROPHORES, MOLECULAR COMPLEXES, SENSORS, AND METHODS OF USE THEREOF CORNELL UNIVERSITY (US) 2023-06-01 WO disclosed
US-11629131-B2 Coupled recognition/detection system for in vivo and in vitro use CORNELL UNIVERSITY (US) 2023-04-18 US disclosed
US-11453646-B2 Methods for RNA detection and quantification CORNELL UNIVERSITY (US) 2022-09-27 US disclosed
US-10444224-B2 Method for RNA detection and quantification CORNELL UNIVERSITY (US) 2019-10-15 US disclosed
US-20190185434-A1 COUPLED RECOGNITION/DETECTION SYSTEM FOR IN VIVO AND IN VITRO USE UNIV CORNELL (US) 2019-06-20 US disclosed
US-20190185934-A1 METHODS FOR RNA DETECTION AND QUANTIFICATION UNIV CORNELL (US) 2019-06-20 US disclosed
US-10316000-B2 Coupled recognition/detection system for in vivo and in vitro use CORNELL UNIVERSITY (US) 2019-06-11 US disclosed
EP-2398775-B1 COUPLED RECOGNITION/DETECTION SYSTEM FOR IN VIVO AND IN VITRO USE UNIV CORNELL (US) 2019-04-24 EP disclosed
US-9664676-B2 RNA sequences that induce fluorescence of small molecule fluorophores CORNELL UNIVERSITY (US) 2017-05-30 US disclosed
US-20150141282-A1 RNA SEQUENCES THAT INDUCE FLUORESCENCE OF SMALL MOLECULE FLUOROPHORES NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2015-05-21 US disclosed
US-20140220560-A1 METHODS FOR RNA DETECTION AND QUANTIFICATION CORNELL UNIVERSITY (US) 2014-08-07 US disclosed
WO-2013016694-A2 METHODS FOR RNA DETECTION AND QUANTIFICATION CORNELL UNIVERSITY (US) 2013-01-31 WO disclosed
US-20120252699-A1 COUPLED RECOGNITION/DETECTION SYSTEM FOR IN VIVO AND IN VITRO USE CORNELL UNIVERSITY (US) 2012-10-04 US disclosed
EP-2398775-A1 COUPLED RECOGNITION/DETECTION SYSTEM FOR IN VIVO AND IN VITRO USE Cornell University (US) 2011-12-28 EP disclosed
WO-2010096584-A1 COUPLED RECOGNITION/DETECTION SYSTEM FOR IN VIVO AND IN VITRO USE CORNELL UNIVERSITY (US) 2010-08-26 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11453646-B2 Methods for RNA detection and quantification SNRPE, NSUN3, EFTUD2 TSHR 720/4885
US-11629131-B2 Coupled recognition/detection system for in vivo and in vitro use DCLRE1B, TLR9, APEX1 TSHR 774/4885
US-10316000-B2 Coupled recognition/detection system for in vivo and in vitro use DCLRE1B, TLR9, APEX1 TSHR 774/4885
US-20120252699-A1 COUPLED RECOGNITION/DETECTION SYSTEM FOR IN VIVO AND IN VITRO USE DCLRE1B, TLR9, APEX1 TSHR 774/4885
US-20190185434-A1 COUPLED RECOGNITION/DETECTION SYSTEM FOR IN VIVO AND IN VITRO USE DCLRE1B, TLR9, APEX1 TSHR 774/4885
US-10444224-B2 Method for RNA detection and quantification SNRPE, NSUN3, EFTUD2 TSHR 679/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.