Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 1/20 | 0.46 |
| ▸ | LOXL2 | Q9Y4K0 | 3/20 | 0.40 |
| ▸ | HTR2C | P28335 | 1/20 | 0.38 |
| ▸ | TDO2 | P48775 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.37 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.33 |
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.33 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | MAOA | P21397 | 2/20 | 0.32 |
| ▸ | LOX | P28300 | 1/20 | 0.32 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.31 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.31 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.31 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.31 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4652501 | 0.80 | DPP4 (0.47) | LOXL2TDO2TAAR1NOTUMRAB9A | |
| SCHEMBL10950612 | 0.71 | MAPK14 (0.79) | MAPK14TDO2PTGS1PTGS2NOTUM | |
| SCHEMBL16807848 | 0.69 | MAPK14 (0.50) | MAPK14TDO2PTGS2NOTUMNPC1 | |
| SCHEMBL3718608 | 0.69 | MAPK14 (0.46) | MAPK14TDO2PTGS1PTGS2NOTUM | |
| SCHEMBL6633897 | 0.68 | MAPK14 (0.45) | MAPK14TDO2PTGS1NPC1RAB9A | |
| SCHEMBL8138770 | 0.65 | BCL2L1 (0.48) | MAPK14NPC1RAB9A | |
| SCHEMBL3761020 | 0.64 | LOXL2 (0.43) | LOXL2HTR2CTDO2MAOBPTGS1 | |
| SCHEMBL3723618 | 0.64 | DPP4 (0.69) | MAPK14LOXL2HTR2CMAOBPTGS1 | |
| SCHEMBL8133757 | 0.63 | MAPK14 (1.00) | MAPK14 | |
| SCHEMBL7457056 | 0.63 | LOXL2 (0.30) | LOXL2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010129848-A2 | 2,6-DIOXO-1,2,3,6-TETRAHYDROPYRIMIDINE-4-CARBOXAMIDES | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-11-11 | — | — | WO | disclosed |