Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 1/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.40 |
| ▸ | JAK1 | P23458 | 2/20 | 0.37 |
| ▸ | PRKDC | P78527 | 1/20 | 0.36 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.35 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.34 |
| ▸ | SCD | O00767 | 2/20 | 0.34 |
| ▸ | SCD5 | Q86SK9 | 1/20 | 0.34 |
| ▸ | ABL1 | P00519 | 1/20 | 0.33 |
| ▸ | CFTR | P13569 | 1/20 | 0.33 |
| ▸ | GNE | Q9Y223 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | IDH2 | P48735 | 1/20 | 0.33 |
| ▸ | NAPEPLD | Q6IQ20 | 5/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3719037 | 1.00 | PTGS1 (0.40) | PTGS1PTGS2JAK1PRKDCIRAK1 | |
| SCHEMBL117350 | 0.78 | PRKAB2 (0.37) | PTGS1PTGS2PRKDCABL1CFTR | |
| SCHEMBL117351 | 0.78 | PRKAB2 (0.37) | PTGS1PTGS2PRKDCABL1CFTR | |
| SCHEMBL21516108 | 0.78 | PTGS1 (0.42) | PTGS1PTGS2GAAKDM4EALDH1A1 | |
| SCHEMBL2638003 | 0.73 | TTR (0.53) | PRKDCIRAK4GNENAPEPLDKDM4E | |
| SCHEMBL17373798 | 0.73 | TTR (0.53) | PRKDCIRAK4GNENAPEPLDKDM4E | |
| SCHEMBL28842909 | 0.72 | PTGS1 (0.46) | PTGS1PTGS2JAK1GAAGNE | |
| SCHEMBL19996101 | 0.71 | PRKCQ (0.43) | PTGS1PTGS2IRAK4GAA | |
| SCHEMBL29749599 | 0.71 | KDM4E (0.39) | PTGS1PTGS2GAAKDM4E | |
| SCHEMBL9753622 | 0.69 | PTGS1 (0.53) | PTGS1PTGS2GAAGNENPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010126745-A1 | SUBSTITUTED IMIDAZO[1,2-A]PYRIDINE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS, AND METHODS OF USE AS β-SECRETASE INHIBITORS | HIGH POINT PHARMACEUTICALS, LLC (US) | 2010-11-04 | — | — | WO | disclosed |