Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | GLA | P06280 | 1/20 | 0.47 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.38 |
| ▸ | BACE1 | P56817 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.34 |
| ▸ | ACACB | O00763 | 3/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | APEX1 | P27695 | 1/20 | 0.33 |
| ▸ | TLR8 | Q9NR97 | 3/20 | 0.33 |
| ▸ | PNMT | P11086 | 1/20 | 0.33 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3720478 | 0.85 | GLA (0.40) | SMN1; SMN2GLACSNK2A1CYP1A2CYP3A4 | |
| SCHEMBL3726169 | 0.85 | HPGD (0.34) | SMN1; SMN2GLACSNK2A1BACE1CYP1A2 | |
| SCHEMBL3724459 | 0.84 | MTNR1A (0.48) | SMN1; SMN2CYP1A2ACACBMEN1LMNA | |
| SCHEMBL3718574 | 0.83 | GLA (0.53) | SMN1; SMN2GLACSNK2A1BACE1ACACB | |
| SCHEMBL3720106 | 0.81 | SMN1; SMN2 (0.49) | SMN1; SMN2GLACSNK2A1CYP1A2CYP3A4 | |
| SCHEMBL3717279 | 0.80 | GLA (0.57) | SMN1; SMN2GLACSNK2A1BACE1ACACB | |
| SCHEMBL3719337 | 0.80 | HPGD (0.38) | SMN1; SMN2CYP1A2ACACBMEN1LMNA | |
| SCHEMBL3726862 | 0.80 | TSHR (0.36) | SMN1; SMN2GLACYP1A2CYP3A4TSHR | |
| SCHEMBL3726168 | 0.79 | PDE4B (0.41) | SMN1; SMN2CYP1A2MEN1LMNAKMT2A | |
| SCHEMBL3720774 | 0.78 | GLA (0.43) | SMN1; SMN2GLACSNK2A1CYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010127208-A1 | INHIBITORS OF ACETYL-COA CARBOXYLASE | FOREST LABORATORIES HOLDINGS LIMITED (BM) | 2010-11-04 | — | — | WO | disclosed |